Evidence map›Paper›PMID 40776775›Full record

ArticleActa biochimica et biophysica Sinica2025

The TCF7L2/miR-206/Cofilin1 axis promotes the metastasis of bladder cancer cells by regulating the formation of invadopodia.

Yuzhen Jie, Yinggui Yang, Chengyan Guo, Qinghui Wu, Zhewen Ou, Weifu Wang, Ning Xu, Wei Peng, Yingguang Wu, Jiangfan Peng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuzhen JieDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Yinggui YangDepartment of Urology, Shenzhen Hospital of Southern Medical University, Shenzhen 518110, China.
Chengyan GuoDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Qinghui WuDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Zhewen OuDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Weifu WangDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Ning XuDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Wei PengDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Yingguang WuDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.
Jiangfan PengDepartment of Urology, Shenzhen Hospital of Southern Medical University, Shenzhen 518110, China.
Shengchao MaNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 750004, China.
Shufang ZhangCentral Laboratory, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine and Haikou City Key Laboratory of Clinical Medicine, Haikou 570203, China.
Fei WangDepartment of Urology, Affiliated Hainan Hospital of Hainan Medical University, Hainan General Hospital, Hainan Provincial Clinical Medical Center, Haikou 570311, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BCa) is one of the most common malignant tumors of the urinary system, but its pathogenesis is still unclear. T1G3 BCa is particularly invasive and relapses readily after treatment, with progression to invasive cancer or distant metastasis. Therefore, identification of the molecular mechanism by which it invades and metastasizes to guide treatment and predict patient prognosis is needed. Cofilin1 plays an important role in regulating gene expression and the invasiveness of tumors. In this study, we show that Cofilin1 is highly expressed in BCa and lymph nodes with metastasis, which is positively related to the grade of BCa, and is significantly related to clinicopathological parameters and cancer-specific survival. Phenotypic analysis reveals that

Indexed as

Cofilin 1MicroRNAsPodosomesUrinary Bladder NeoplasmsCell Line, TumorCell MovementCell ProliferationCortactinFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisSignal TransductionCFL1 protein, humanCofilin 1CortactinMicroRNAsbladder cancerCofilin1invadopodia formationmetastasis

Identifiers

PMID40776775
PMCPMC13059783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.