Evidence map›Paper›PMID 40776766›Full record

ArticleThe Laryngoscope2026

Laryngeal Vibration to Treat Abductor-Type Laryngeal Dystonia: Effectiveness and Cortical Response.

Arash Mahnan, Jiapeng Xu, Jinseok Oh, Divya Bhaskaran, Yang Zhang, Peter J Watson, Jürgen Konczak

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06111027 (Usability of Laryngeal Vibro-tactile Stimulation as a Non-invasive Treatment for the Voice Disorder Spasmodic Dysphonia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06111027 phase1 / phase2completednot on this map

Usability of Laryngeal Vibro-tactile Stimulation as a Non-invasive Treatment for the Voice Disorder Spasmodic Dysphonia

TypeinterventionalSponsorUniversity of MinnesotaRan2023 to 2024Enrolled40ConditionsSpasmodic Dysphonia, Laryngeal DystoniaArmsVibro-tactile stimulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arash MahnanMeta Reality Labs, Redmond, Washington, DC, USA.ORCID 0000-0003-4097-9308
Jiapeng XuHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Jinseok OhHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Divya BhaskaranHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Yang ZhangDepartment of Speech, Language, and Hearing Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Peter J WatsonDepartment of Speech, Language, and Hearing Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Jürgen KonczakHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-4422-5610

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Dysphonia InternationalNCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114
6 · The paper itself

Abstract

objectivesDemonstrate proof-of-concept that superficial vibro-tactile stimulation (VTS) of the larynx can serve as a non-invasive neuromodulation method to reduce voice symptoms in people with abductor-type laryngeal dystonia (ABLD) and record the underlying neural response to VTS of the somatosensory-motor cortex.

methodsUsing a wearable collar with embedded vibrators, 11 people with ABLD received VTS for 24 min. To assess voice effects, they vocalized vowels and spoke standardized test sentences and words. Cortical activity was recorded using 64-channel EEG. Smoothed cepstral peak prominence, cumulative word and sentence duration were derived from voice recordings as objective markers of speech quality next to perceived speech effort as a subjective marker.

resultsIn response to VTS, 64% of participants rated their improvement in voice quality as noticeable to very noticeable. Analysis of objective voice measures indicated a reduction in voice symptoms in up to 45% of participants immediately after and/or 20 min past the cessation of VTS. The cortical response to VTS application was a reduced event-related spectral power in theta, alpha, and beta bands over left and right somatosensory-motor cortical areas that was most prominent over the left premotor cortex in 7/11 participants.

conclusionApplying laryngeal VTS proved to be feasible and safe. VTS can induce acute short-term reductions in voice symptoms, which is important given the limited therapeutic options for ABLD. The electrocortical correlate of VTS was an event-related desynchronization of neuronal firing patterns over bilateral somatosensory-motor cortex. LEVEL OF EVIDENCE: 4:

Indexed as

DystoniaLaryngeal DiseasesLarynxVibrationAdultAgedElectroencephalographyFemaleHumansMaleMiddle AgedSomatosensory CortexTreatment OutcomeVoice QualityEEGhumansomatosensoryspasmodic dysphoniaspeech

Identifiers

PMID40776766
PMCPMC12770868

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.