Evidence map›Paper›PMID 40776748›Full record

ArticleOncology reports2025

Comprehensive genetic profiling using tissue and blood in locally advanced tumors.

Kenji Fujiyoshi, Rie Sugihara, Naoki Miyamoto, Yoriko Watanabe, Tomoya Sudo, Sanae Numata, Jun Akiba, Hideyuki Abe, Yuka Ichinose, Kenji Inoue and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Kenji FujiyoshiDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Rie SugiharaDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Naoki MiyamotoDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Yoriko WatanabeResearch Institute of Medical Mass Spectrometry, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Tomoya SudoDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Sanae NumataCancer Center, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Jun AkibaDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Hideyuki AbeDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Yuka IchinoseDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Kenji InoueDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Shuichi OzonoDepartment of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Takeharu OnoDepartment of Otolaryngology‑Head and Neck Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Kentaro OriokaCancer Center, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Masaki KashiharaDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Ryousuke KajiwaraDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Hiroyuki KawanoDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Akihiko KawaharaDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Ryuta TakaseDepartment of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Uhi TohDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Kazuaki HashimotoDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Toru HisakaDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Shingo HiraiDivision of Gastroenterology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Masahiro MitsuokaDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Daiki MiyazakiDepartment of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Fumi YoshitomiDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.
Ken YamamotoDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Hirohito UmenoDivision of Gastroenterology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Masahisa NomuraDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan.
Yoshiki NaitoDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 8300011, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comprehensive genomic profiling (CGP) aims to assist clinicians with the diagnosis, treatment decisions and early detection of recurrence in patients with cancer. CGP using tumor tissue is widely implemented, whereas circulating tumor DNA (ctDNA) analysis is a noninvasive method that uses peripheral blood. This pilot study included eight patients with locally advanced tumors (two each of breast, lung, pancreatic, and head and neck cancers). The concordance of somatic variants with tumor tissues and paired ctDNA from pre‑ and post‑resection samples was evaluated. This study demonstrated that the overall concordance rate in all genes between tissue and postoperative blood was high (94.2%), but the concordance rate in genes with somatic variants was low (4.76%). In patient 8 with head and neck cancer, the

Indexed as

Biomarkers, TumorCirculating Tumor DNANeoplasm Recurrence, LocalNeoplasmsAdultAgedFemaleGene Expression ProfilingHumansLung NeoplasmsMaleMiddle AgedMutationPancreatic NeoplasmsPilot ProjectsBiomarkers, TumorCirculating Tumor DNAbiomarkercirculating tumor DNAcomprehensive genomic profilingliquid biopsyprecision medicine

Identifiers

PMID40776748
PMCPMC12351229

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.