Evidence map›Paper›PMID 40776687›Full record

SynthesisGut and liver2025

Dietary β-Carotene, Vitamin A, and Retinol Intake and Prevalence of Colorectal Adenoma: A Cross-Sectional Study and Meta-Analysis.

Joowon Chung, Jioh Kang, Sang Hoon Kim, Min Kyu Jung, Dong Hyun Kim, Hyun Joo Song, Ki Bae Kim, Seung-Joo Nam, Hoon Jai Chun, Jung Eun Lee and 2 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gut and liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joowon ChungDepartment of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.ORCID 0000-0003-1572-8056
Jioh KangDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea.ORCID 0009-0003-9035-9999
Sang Hoon KimDivision of Gastroenterology, Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.ORCID 0000-0003-3548-1986
Min Kyu JungDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.ORCID 0000-0001-8749-408X
Dong Hyun KimDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.ORCID 0000-0001-5778-1264
Hyun Joo SongDepartment of Internal Medicine, Jeju National University College of Medicine, Jeju, Korea.ORCID 0000-0002-2561-555X
Ki Bae KimDepartment of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.ORCID 0000-0001-6372-432X
Seung-Joo NamDepartment of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.ORCID 0000-0002-0349-0901
Hoon Jai ChunDepartment of Internal Medicine, Institute of Gastrointestinal Medical Instrument Research, Korea University College of Medicine, Seoul, Korea.ORCID 0000-0002-5539-361X
Jung Eun LeeDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea.ORCID 0000-0003-1141-878X
Yun Jeong LimDepartment of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University, College of Medicine, Goyang, Korea.ORCID 0000-0002-3279-332X
Korean GI Nutrition Study Group(K-GINUS)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Antioxidants may offer protection against colorectal cancer, but their association with colorectal adenomas remains unclear due to variations in study design, population, and dietary factors. We investigated the relationship between dietary intake of β-carotene, vitamin A, and retinol and the prevalence of colorectal adenoma using food frequency questionnaires (FFQs) and colonoscopy data. Methods: We recruited participants undergoing elective colonoscopy across eight medical institutions. FFQs were administered prior to colonoscopy, and nutrient intakes were categorized into quartiles. Multivariate logistic regression was used to estimate odds ratios (ORs) adjusting for potential cofounders. A meta-analysis of 11 observational studies, including our own, was also conducted. Results: Among 720 eligible participants (mean age 52.44±14.30 years; body mass index 23.82±3.46 kg/m Conclusions: We demonstrated an inverse association between β-carotene and colorectal adenoma prevalence, whereas the effects of vitamin A and retinol appeared to vary depending on dietary context. These findings highlight the complex influence of dietary pattern and nutrient sources on colorectal adenoma risk.

Indexed as

Adenomabeta CaroteneColorectal NeoplasmsDietVitamin AAdultAgedColonoscopyCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalencebeta CaroteneVitamin AAntioxidantsColorectal adenomaRetinolVitamin Aβ-Carotene

Identifiers

PMID40776687
PMCPMC12616148

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.