ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2025
Evaluation of abdominal massage as a non-pharmacological modality to restore gut microbiota and duodenal barrier function in a rat model of functional dyspepsia.
Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 1 paper.
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1 citing paper in PubMed.
- Effect of a multimodal bundled intervention on quality of recovery after laparoscopic colorectal cancer surgery: a single-center, single-blind, pragmatic randomized controlled trial.World journal of surgical oncology · 2026Trial
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BackgroundFunctional dyspepsia (FD) is a prevalent gastrointestinal disorder associated with impaired motility, mucosal barrier disruption, and dysbiosis of intestinal microbiota. While pharmacological treatments exist, non-invasive therapeutic approaches leveraging traditional medicine are gaining attention for their holistic benefits and minimal side effects.ObjectiveThis study aimed to evaluate the therapeutic impact of abdominal massage, a non-pharmacological intervention rooted in Traditional Chinese Medicine (TCM), on gastrointestinal motility, duodenal barrier integrity, and gut microbiota in a rat model of FD.MethodsEighteen male rats were assigned to control, model, and massage groups. The FD model was established via multifactorial stress. The massage group underwent daily abdominal massage for 7 days. Food intake, body weight, gastric emptying, and intestinal propulsion were assessed. Duodenal tissue morphology, expression of tight junction proteins (occludin and claudin-1), and intestinal microbiota profiles (via 16S rRNA sequencing) were analyzed using histological, immunofluorescence, and high-throughput sequencing technologies.ResultsAbdominal massage significantly improved gastric emptying and intestinal propulsion in FD rats. Histological examination revealed restoration of duodenal villi architecture, and immunofluorescence showed increased expression of occludin and claudin-1. Microbiota analysis suggested a shift toward a more balanced community, with trends indicating increased abundance of beneficial taxa such as Enterococcaceae and Lachnospiraceae.ConclusionAbdominal massage effectively enhances gastrointestinal motility, suggests potential to promote intestinal microbiota homeostasis, and repairs mucosal barrier dysfunction in FD rats. These findings suggest the potential of massage therapy as a safe, non-invasive, and technologically integrable modality in the management of gastrointestinal disorders.
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