Evidence map›Paper›PMID 40776598›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Outcomes After Tonsillectomy in Children With Angelman Syndrome.

Meera Chopra, Jennifer M Siu, Erick Sell, Jane Summers, Jackie Chiang, Evan J Propst, Evelina Pankiv, Nikolaus E Wolter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meera ChopraDepartment of Otolaryngology - Head and Neck Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID 0009-0009-1283-3951
Jennifer M SiuDepartment of Otolaryngology - Head and Neck Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID 0009-0007-1040-725X
Erick SellDivision of Neurology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
Jane SummersDepartment of Psychiatry, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Jackie ChiangDivision of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Evan J PropstDepartment of Otolaryngology - Head and Neck Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Evelina PankivDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Nikolaus E WolterDepartment of Otolaryngology - Head and Neck Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ImportanceAngelman syndrome is a rare genetic disorder characterized by developmental delay, sleep disturbances, and a happy demeanor. Tonsillectomies are common procedures for individuals with Angelman syndrome, and their postoperative recovery may be complicated by challenging pain assessments, respiratory complications, or feeding difficulties. Inappropriate laughing may mask perioperative pain and anxiety.ObjectiveThe objective of this study is to review postoperative outcomes and complications of children with Angelman syndrome undergoing tonsillectomy.Methods (Design, Setting, Participants, Intervention, Measures)We conducted a retrospective review of patients with Angelman syndrome undergoing tonsillectomies from 2000 to 2024 in a quaternary pediatric hospital. Demographic, clinical, and surgical outcome variables were collected.ResultsTwelve children with Angelman syndrome underwent tonsillectomy: 7 for sleep-disordered breathing, 4 for sialorrhea, and 1 for recurrent tonsillitis. Median (IQR) duration of stay was 4.0 (3.0-5.3) days. The most common reason for prolonged hospital stay was inadequate oral intake. Nine (75.0%) children experienced postoperative complications, most frequently pooling of secretions and oxygen desaturations. Three children (25.0%) experienced severe postoperative complications, including 1 opioid overdose, 1 respiratory distress, and 1 aspiration pneumonia. Two patients were readmitted to the hospital: 1 for irregular breathing and poor pain control, and 1 for epistaxis.ConclusionThe postoperative course following tonsillectomy in children with Angelman syndrome can be complicated by a prolonged recovery, inadequate pain control, opioid toxicity, respiratory complications, and poor oral intake. Caregiver input on pain behavior is critical to develop an effective postoperative management strategy.RelevanceBased on our results and a literature review, we have created recommendations for post-tonsillectomy care in children with Angelman syndrome.

Indexed as

Angelman SyndromeTonsillectomyAdolescentChildChild, PreschoolFemaleHumansLength of StayMalePostoperative ComplicationsRetrospective StudiesSleep Apnea SyndromesTonsillitisTreatment OutcomeAngelman syndromechildrenpainpostoperative complicationstonsillectomy

Identifiers

PMID40776598
PMCPMC12334819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.