ReviewCell cycle (Georgetown, Tex.)
Unfolded protein response complexity in gynecological tumor dynamics: therapeutic challenges and future perspectives.
Review in Cell cycle (Georgetown, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Therapeutic optimization of LIPA targeting to induce endoplasmic reticulum stress and cell death in ovarian cancer.Oncogene · 2026Article
- Targeting the Endoplasmic Reticulum Oxidoreductin-1 Alpha-Protein Disulfide Isomerase Redox Interface as a Therapeutic Strategy in Cancer.Biomedicines · 2026Review
- Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress.Apoptosis : an international journal on programmed cell death · 2026Article
- Molecular crossroads: identifying MAPK proteins bridging SMAD and dopamine pathways in breast cancer.Cell cycle (Georgetown, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer cells frequently undergo stresses like hypoxia, glucose deprivation, and calcium depletion, leading to protein misfolding and accumulation of unfolded proteins in the ER, which trigger ER stress. The unfolded protein response (UPR) is activated by endoplasmic reticulum (ER) stress to restore protein homeostasis by regulating protein synthesis and degradation. This review explores the multifaceted role of UPR in tumor growth, chemoresistance, and immune evasion in gynecological cancers, particularly ovarian, endometrial, and cervical cancers. UPR-associated genes have been reported to have a potential role as disease biomarkers and therapeutic targets, thus improving early detection and personalized treatment. This review aims to give insights into the role of UPR pathway in gynecological cancers and offers new perspectives for future research and clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.