Evidence map›Paper›PMID 40776530›Full record

ArticleWorld journal of surgery2025

Recurrent Nonobstructive Cholangitis After Pancreaticoduodenectomy: Prevalence, Risk Factors, and Treatment.

Anaïs Choquet, Aurélien Sokal, Safi Dokmak, Audrey Le Bot, Fanny Delahaye, Jeanne Dembinski, Béatrice Aussilhou, Vinciane Rebours, Victoire de Lastours, Alain Sauvanet

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Article in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anaïs ChoquetDepartment of HPB Surgery, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Aurélien SokalDepartment of Internal Medecine, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Safi DokmakDepartment of HPB Surgery, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Audrey Le BotDepartment of Internal Medecine, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Fanny DelahayeDepartment of HPB Surgery, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Jeanne DembinskiDepartment of HPB Surgery, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Béatrice AussilhouDepartment of HPB Surgery, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Vinciane ReboursDepartment of Pancreatology, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Victoire de LastoursDepartment of Internal Medecine, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.
Alain SauvanetDepartment of HPB Surgery, AP-HP, Beaujon Hospital, University of Paris-Cité, Clichy, France.ORCID https://orcid.org/0000-0002-7436-5999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecurrent nonobstructive cholangitis (RNOC) due to enterobiliary reflux is a late complication of pancreaticoduodenectomy (PD) that should be differentiated from obstructive cholangitis. The risk factors (RFs) of RNOC are poorly known. The goal of this study was to estimate the prevalence, to identify the RF, and to describe the management of RNOC following PD.

methodsThis case-control study included 503 patients from a prospective database (2014-2018) who underwent PD; one hundred and eighty-three patients were excluded because they had less than 1-year of follow-up, tumor recurrence during postoperative year one, or cholangitis from anastomotic stenosis or tumor recurrence. RNOC was defined as at least 3 episodes of cholangitis that occurred or persisted more than 1-year after PD, without anastomotic stenosis or tumor recurrence. RF were identified by univariate and multivariate analyses.

resultsOf the 320 analyzed patients, 213 (67%) and 107 (33%) underwent PD for malignancy and a benign lesion, respectively. With a median follow-up of 47 months (IQR: 33-68), 27 of the 320 patients (8%) developed RNOC (median number of episodes = 8 and IQR = 5-12). The only independent RF for RNOC was noninvasive IPMN (OR = 3.222; IC-95% = 1.219-8.514; and p = 0.018). All patients received on-demand antibiotics. Three patients (11%) developed complications from RNOC (hepatic abscesses in 3 and organ failure in one). No patients died from RNOC. Two (7%) patients underwent reoperation to lengthen the biliary Roux-en-Y loop but RNOC persisted in both.

conclusionsRNOC complicates 8% of PD. Noninvasive IPMN was a RF of RNOC. The value of revision surgery to limit the risk of recurrence seems limited.

Indexed as

CholangitisPancreaticoduodenectomyPostoperative ComplicationsAgedCase-Control StudiesFemaleHumansMaleMiddle AgedPancreatic NeoplasmsPrevalenceRecurrenceRisk FactorscholangitisIPMNpancreaticoduodenectomypostoperative complications

Identifiers

PMID40776530
PMCPMC12435610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.