Evidence map›Paper›PMID 40776529›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Novel Swelling-Lytic Cell Death Triggered by Cargo-Free Ionizable Lipid Nanoparticles.

Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Novel Swelling-Lytic Cell Death Triggered by Cargo-Free Ionizable Lipid Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junjun WuKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.ORCID https://orcid.org/0000-0001-6113-8976
Zhennan ZhaoKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Hongsheng WuKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Sihuang LinFirst Hospital of Quanzhou Affiliated with Fujian Medical University, Quanzhou, 362000, China.
Lin HuangKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Guanjie ChenKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Yi YangKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Hong WangKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Huijie YanKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Yonghui ShiKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Liuyu ZhuKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Guosheng HuKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.
Liling ZhengFirst Hospital of Quanzhou Affiliated with Fujian Medical University, Quanzhou, 362000, China.
Songying OuyangKey Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University Provincial University, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, 350117, China.ORCID https://orcid.org/0000-0002-1120-1524

Funding

Fujian Provincial Foundation for Education and Scientific Research Projects of Young and Middle-aged Teachers JAT220044Guiding Funds of Central Government for Supporting the Development of the Local Science and Technology 2024L3008National Natural Science Foundation of China 22237003National Natural Science Foundation of China 22307019National Natural Science Foundation of China 82172287National Natural Science Foundation of China 82225028Natural Science Foundation of Fujian Province 2023J01506Natural Science Foundation of Fujian Province 2025J09032State Key Laboratory of Vaccines for Infectious Diseases/Xiang An Biomedicine Laboratory 2023XAKJ0101011
6 · The paper itself

Abstract

Lipid nanoparticles (LNPs) are recognized as robust and versatile drug delivery platforms holding significant promise for personalized and precision medicine applications. However, their intrinsic biological effects, including dose-limiting toxicity and acute inflammation, limit their widespread application. Elucidating the underlying mechanisms paradoxically enables dual-path optimization: targeted mitigation strategies for adverse effects and deliberate amplification of adverse effects for repurposing ("waste-to-resource"). Here, cargo-free lipid nanoparticles containing the ionizable phospholipid IP9 (ipLNP) are found to induce broad swelling (bubble) morphology and lytic cell death across multiple cell types. ipLNP-induced cell death involves reactive oxygen species (ROS) increase, lipid peroxidation, and GSDME cleavage, but is only inhibited by vitamin E among the tested inhibitors. By exploring the effects of vitamin E, lysosome-associated lytic cell death is found to be triggered by ipLNP and mediated by lysosome membrane destabilization. Moreover, ipLNP exhibits remarkable potential as novel Th1/Th17-directing vaccine adjuvants and emerging cancer therapeutic agents, not merely as drug carriers.

Indexed as

Cell DeathLipidsNanoparticlesAnimalsDrug Delivery SystemsHumansReactive Oxygen SpeciesVitamin ELipidsReactive Oxygen SpeciesVitamin Eadjuvantcancer therapyinflammationlipid nanoparticleslytic cell death

Identifiers

PMID40776529
PMCPMC12561346

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.