Evidence map›Paper›PMID 40776481›Full record

ArticleEuropean journal of immunology2025

Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis.

Sarah Schmidiger, Erin F McCaffrey, Jan M Schmidt, Owais Abdul Hameed, Max Mpina, Anneth Tumbo, Elirehema Mfinanga, Frederick Haraka, Hellen Hiza, Mohamed Sasamalo and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. CD8+ lymphocytes in immunity against tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sarah SchmidigerSwiss Tropical and Public Health Institute, Allschwil, Switzerland.ORCID 0009-0008-1791-4104
Erin F McCaffreyLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jan M SchmidtTranslational Medicine-Preclinical Safety, Novartis Biomedical Research, Basel, Switzerland.ORCID 0009-0005-8356-4067
Owais Abdul HameedAnatomy Unit, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Max MpinaIfakara Health Institute, Bagamoyo, Tanzania.
Anneth TumboIfakara Health Institute, Bagamoyo, Tanzania.
Elirehema MfinangaIfakara Health Institute, Bagamoyo, Tanzania.
Frederick HarakaIfakara Health Institute, Bagamoyo, Tanzania.
Hellen HizaSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Mohamed SasamaloSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Jerry HellaIfakara Health Institute, Bagamoyo, Tanzania.
Michael WalchAnatomy Unit, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Jacques FellaySchool of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Sébastien GagneuxSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Klaus ReitherSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
José M CarballidoTranslational Medicine-Preclinical Safety, Novartis Biomedical Research, Basel, Switzerland.ORCID 0000-0001-8465-0665
Ainhoa ArbuésSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Damien PortevinSwiss Tropical and Public Health Institute, Allschwil, Switzerland.ORCID 0000-0003-2949-9557

Funding

European and Developing Countries Clinical Trials PartnershipSwiss National Science Foundation 197838 and 177163
6 · The paper itself

Abstract

Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an infection. Containment is exploited by Mtb as a hideout to persist in a dormant, antibiotic-tolerant state, only to resuscitate upon immunosuppression. The immune determinants of a granulomatous response driving Mtb persistence remain elusive. We here generated ex vivo granuloma-like structures from peripheral blood mononuclear cell specimens of TB patients and applied high-dimensional mass cytometry to elucidate immune factors prompting Mtb dormancy. Compared with healthy controls, patient-derived specimens rapidly forced Mtb to become dormant-like ex vivo. This observation correlated with an enrichment in activated, innate (-like) cytotoxic lymphocytes and required the presence of CD56

Indexed as

Antigens, Differentiation, T-LymphocyteGranulomaLeukocytes, MononuclearMycobacterium tuberculosisTuberculosisAdultCD56 AntigenFemaleHumansMaleMiddle AgedAntigens, Differentiation, T-LymphocyteCD56 AntigenGNLY protein, humanbacterial infectionscellular immunologyCyTOFcytotoxicitydormancygranulomagranulysinimmune evasionMycobacterium tuberculosisNK cells

Identifiers

PMID40776481
PMCPMC12332329

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.