ArticleAdvanced healthcare materials2025
Particle Shape Modulates the Function of Adoptive Macrophage Transfers.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Shape-Programmable Particles from Photocurable Poly(β-Amino Esters) for Drug Delivery Applications.Advanced functional materials · 2026Article
- Revisiting Colloid Theory for Biomedicine: Reconciling Simple Models in Complex Environments.ACS nano medicine · 2026Article
- Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential.npj biomedical innovations · 2026Review
- Transport of Adoptive Cell Transfers With Magnetic Helical Microrobots.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Adoptive cell transfers (ACTs) constitute an emerging platform for improving the systemic delivery of nano- and microparticle systems. Macrophages (Mφ) are an attractive cell type for particle-carrying ACTs because their attachment, phagocytosis, and chemotaxis can improve pharmacokinetics and reduce off-target effects. However, little is known about how macrophage transport and function change when carrying particles of different shapes, or whether these changes can be leveraged for improving ACTs. This work investigates macrophage interactions with biodegradable spherical and discoidal particles to promote or suppress phagocytosis, respectively. Adoptively transferred macrophages with internalized spheres (Mφ-S) or surface-bound discs (Mφ-D) possess enhanced targeted delivery to solid tumors compared to conventional free microparticle administration by 5.2-fold and exhibit distinct phenotypic profiles within the cold B16-F10 tumor microenvironment. Moreover, phenotypic changes are evaluated upon particle association by profiling the transcriptional, chromatin accessibility, and protein state. Mφ-S complexes adopt epigenetic changes and key biomarkers associated with a proinflammatory phenotype. In Mφ-D complexes, a diverse chromatin and protein landscape with simultaneous upregulation of both pro- and anti-inflammatory biomarkers is observed, suggesting functional flexibility is observed. These findings suggest particle shape can be used as a design parameter to influence the function of adoptive macrophage transfers without compromising their delivery performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.