Effect of internet-delivered exposure therapy versus healthy lifestyle promotion for patients with persistent physical symptoms (SOMEX1): a randomized controlled trial with planned moderator analysis.
Trial report in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Internet-delivered Exposure-based Treatment vs. Standardized Education for Distress Related to Somatic Symptoms in Primary Care
TypeinterventionalSponsorRegion StockholmRan2021 to 2025Enrolled161ConditionsSomatic Symptom and Related Disorders, Medically Unexplained Symptoms, Psychological Factors Affecting Other Medical ConditionsArmsExposure, Standardized education, Prolonged assessment
NCT07757854 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation
Randomized Controlled Dismantling Trial of Exposure Therapy for Reactivity to Symptoms
TypeinterventionalSponsorRegion StockholmRan2026 to 2031Enrolled360ConditionsPsychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders, Bodily Distress DisorderArmsPlanned, systematic, exposure exercises, Response prevention
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Jonna HybeliusDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, https://ror.org/056d84691Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1593-3431
Sandra Af Winklerfelt HammarbergDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, https://ror.org/056d84691Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5873-1568
Sigrid SalomonssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID 0000-0002-6713-5933
Caroline WachtlerDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, https://ror.org/056d84691Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1317-7732
Majken EpsteinLiljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden.ORCID 0000-0001-8397-5986
Anna OlssonLiljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden.
Emma StrandLiljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden.
Lina Söderström WinterLiljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden.
Tomas ÅkerlundLiljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden.
Daniel BjörkanderLiljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden.
Amanda KosicSchool of Law, Psychology and Social Work, https://ror.org/05kytsw45Örebro University, Örebro, Sweden.ORCID 0000-0001-7975-4558
Gabriel ChahinLiljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre, Region Stockholm, Stockholm, Sweden.ORCID 0009-0002-5679-9985
John WallertCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID 0000-0002-1473-4916
Eva Toth-PalDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, https://ror.org/056d84691Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7721-3272
Steven NordinDepartment of Psychology, https://ror.org/05kb8h459Umeå University, Umeå, Sweden.ORCID 0000-0003-1699-1681
Erland AxelssonDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, https://ror.org/056d84691Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2562-2925
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundThe management of persistent physical symptoms poses a challenge in many healthcare settings, including primary care. Psychological treatments that involve exposure have shown promise for several conditions where patients suffer from persistent physical symptoms and unwanted responses to these. It is unclear, however, to what extent exposure therapy has effects beyond existing routine care interventions and who benefits the most.
methodsA randomized controlled trial at a primary care center in Stockholm, Sweden compared 10 weeks of internet-delivered exposure therapy (
resultsPatients contributed 1544 datapoints during treatment. The primary analysis showed no significant advantage of exposure therapy versus HLP in the reduction of mean somatic symptom burden (
conclusionsExposure therapy does not appear to show noteworthy average benefit over HLP, with the exception of symptom preoccupation. Substantial benefits are seen in patients with very high symptom burden or symptom preoccupation.
Indexed as
Health PromotionHealthy LifestyleImplosive TherapyInternetInternet-Based InterventionMedically Unexplained SymptomsAdultAgedAnxietyFemaleHumansMaleMiddle AgedPrimary Health CareSwedenTreatment Outcomeexposure therapyhealthy lifestyle promotioninternet-basedmoderator analysispersistent physical symptomsprimary carerandomized controlled trialtransdiagnostic
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Effect of internet-delivered exposure therapy versus healthy lifestyle promotion for patients with persistent physical symptoms (SOMEX1): a randomized controlled trial with planned moderator analysis. · full record | OpenQuestion