Evidence map›Paper›PMID 40775748›Full record

ArticleBMC infectious diseases2025

Urinary pneumococcal serotype detection among children with and without community-acquired pneumonia.

Lilliam Ambroggio, Lindsay R Grant, Jillian M Cotter, Samuel R Dominguez, Daniel Olson, Sara R Saporta-Keating, Cody Bender, Mohammad Ali, Kathleen Grice, Gonzalo Lerner and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lilliam AmbroggioSection of Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA. Lilliam.Ambroggio@cuanschutz.edu.
Lindsay R GrantPfizer, Inc., 500 Arcola Road, Collegeville, PA, USA.
Jillian M CotterSection of Hospital Medicine, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Samuel R DominguezSection of Infectious Diseases, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Daniel OlsonSection of Infectious Diseases, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Sara R Saporta-KeatingSection of Infectious Diseases, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Cody BenderPfizer, Inc., 500 Arcola Road, Collegeville, PA, USA.
Mohammad AliPfizer, Inc., 500 Arcola Road, Collegeville, PA, USA.
Kathleen GriceSection of Infectious Diseases, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Gonzalo LernerSection of Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Michael W PrideVaccine Research and Development, Pfizer Vaccines, Pearl River, NY, USA.
Ashley MillerPfizer, Inc., 500 Arcola Road, Collegeville, PA, USA.
Maria J TortPfizer, Inc., 500 Arcola Road, Collegeville, PA, USA.
Annaellis VaughanSection of Infectious Diseases, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Elizabeth TemteSection of Hospital Medicine, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Alec EdidSection of Emergency Medicine, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Alejandro CanéPfizer, Inc., 500 Arcola Road, Collegeville, PA, USA.
Kristina G HultenInfectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Jill SteinDepartment of Radiology, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.
Bradford D GessnerPfizer, Inc., 500 Arcola Road, Collegeville, PA, USA.
Edwin J AsturiasSection of Infectious Diseases, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Aurora, CO, USA.

Funding

Pfizer Inc. WI253501
6 · The paper itself

Abstract

backgroundUrinary antigen detection (UAD) assays can address diagnostic challenges with culture-based identification of S. pneumoniae. We aimed to evaluate the utility of Pfizer's UAD1 and UAD2 assays for pneumococcal serotype surveillance in children with community acquired pneumonia (CAP) or upper respiratory tract infections (URI).

methodsFrom March 2021-December 2023, children 3 months to 5 years who presented to the Children's Hospital Colorado Emergency Department with respiratory symptoms were enrolled as CAP or URI; healthy children served as controls. Nasal swabs were tested for pneumococcus by PCR. UAD assays identified pneumococcal serotypes from urine. Groups were compared using descriptive statistics.

resultsWe enrolled 407 controls, 202 with URI, and 280 with CAP. Positivity thresholds were set for all UAD serotypes. Pneumococcal nasal swab positivity was 23% for CAP, 17% for URI, and 3% in controls. Serotypes 3, 15B/C, 19 F, and 35B were frequent in nasal swabs in children with CAP or URI. UAD identified serotypes in 13% with CAP and 5% with URI. The most common urine serotypes were 19 F, 22 F, and 9 N. Among children with a nasal swab collected, 28/190 (15%) with CAP and 4/135 (3%) with URI had a positive UAD; 7 (3.7%) and 2 (1.5%), respectively, were the same serotype identified by nasal swab.

conclusionsUAD may be useful in differentiating pneumococcal serotypes in children with CAP and URI from controls. For most, serotypes identified in nasal swabs were not those identified by UAD suggesting UAD positivity was not due to pneumococcal carriage. The Pfizer UAD assay could be utilized for population monitoring of serotype distribution among children with CAP.

Indexed as

Antigens, BacterialCommunity-Acquired InfectionsPneumonia, PneumococcalStreptococcus pneumoniaeChild, PreschoolCommunity-Acquired PneumoniaFemaleHumansInfantMaleRespiratory Tract InfectionsSerogroupAntigens, BacterialAcute respiratory infectionsPediatricsPneumococcusSerotype

Identifiers

PMID40775748
PMCPMC12329884

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.