Evidence map›Paper›PMID 40775742›Full record

ArticleJournal of cardiovascular electrophysiology2025

Hemolysis Induced by Pulsed-Field Ablation of Atrial Arrhythmias: A Comparative Analysis of Current Systems.

Johannes Bruss, Thomas Kueffer, Hildegard Tanner, Fabian Noti, Andreas Haeberlin, Gregor Thalmann, Nikola Asenov Kozhuharov, Boldizsar Kovacs, Valon Spahiu, Claudia Herrera Siklody and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Variable-loop circular vs. Pentaspline catheter: hemolysis outcomes in pulsed-field ablation procedures for atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  3. Haemolysis and renal effects across pulsed field ablation systems in atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Johannes BrussDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-5013-6905
Thomas KuefferDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0003-3553-4945
Hildegard TannerDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Fabian NotiDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andreas HaeberlinDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-9283-0110
Gregor ThalmannDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Nikola Asenov KozhuharovDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Boldizsar KovacsDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Valon SpahiuDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Claudia Herrera SiklodyDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Tobias ReichlinDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-7197-8415
Laurent RotenDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-0827-1329

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

introductionPulsed-field ablation (PFA) is an emerging technology associated with dose-dependent hemolysis as a recently recognized side effect. This study aimed to compare hemolysis levels and assess dose-dependency across three PFA systems: a pentaspline catheter (PSC), a lattice-tip focal catheter (LTFC), and a variable loop circular catheter (VLCC).

methodsPatients treated for atrial arrhythmias with the LTFC (n = 29) or the VLCC (n = 30) were included from a prospective registry. A matched cohort of patients treated with the PSC (n = 28) was recruited from the same registry. Creatinine levels and markers of hemolysis were measured pre-ablation and 1 day postablation.

resultsHaptoglobin levels decreased significantly more with the PSC and VLCC compared to the LTFC (-0.65 [-0.76, -0.49] g/L; -0.56 [-0.78, -0.43] g/L, -0.21 [-0.32, -0.1] g/L, respectively; p < 0.001 for both). Per-application decreases in haptoglobin also differed (-17.5 [-20.38, -13.58] mg/L, -24.35 [-36.36, -17.92] mg/L, -3.61 [-5.98, -2.13] mg/L, respectively; p < 0.001 for both). There was no significant difference in haptoglobin decrease between the PSC and VLCC per procedure (p = 1.0). Haptoglobin decrease per application was significantly larger with the VLCC compared to the PSC (p = 0.0048). Per procedure LDH increase followed a similar trend (49 [18, 81.25] U/L; 14 [6, 60] U/L; 13 [-4, 46] U/L; respectively; p = 0.037). No hemolysis-related complications were observed.

conclusionsHemolysis levels vary significantly among PFA platforms. Focal PFA catheters induce less hemolysis per procedure and application compared to large-footprint catheters.

Indexed as

Atrial FibrillationCardiac CathetersCatheter AblationHemolysisAgedBiomarkersCreatinineEquipment DesignFemaleHaptoglobinsHeart RateHumansMaleMiddle AgedProspective StudiesRegistriesBiomarkersCreatinineHaptoglobinsHP protein, humanatrial arrhythmiaatrial fibrillationatrial flutterhemolysislattice tip focal catheterpentaspline catheterpulmonary vein isolationpulsed‐field ablationvariable loop circular catheter

Identifiers

PMID40775742
PMCPMC12530677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.