Evidence map›Paper›PMID 40775738›Full record

ArticleRenal failure2025

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate AKI after cardiac surgery by facilitating miR-21-5p targeting TEAD1.

Zhengmin Li, Fang He, Shuyang Dai, Qingqing Yu, Chenchen Si, Fan Wu, Wenxin Zhao, Biyao Zhang, Poshi Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhengmin LiDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Fang HeOperating Room, Woman & Infants Hospital of Zhengzhou, Zhengzhou, Henan, China.
Shuyang DaiDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Qingqing YuDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Chenchen SiDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Fan WuDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Wenxin ZhaoDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Biyao ZhangDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
Poshi XuDepartment of Medical Laboratory, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a common complication of cardiac surgery. Human umbilical cord mesenchymal stem cell (hUCMSC)-derived exosomes affect tissue damage and repair, and miR-21-5p reduces apoptosis and inflammation. However, miR-21-5p's role in cardiac surgery remains unclear.

methodsKidney injury molecule (KIM-1), neutrophil gelatinase-associated lipid carrier protein (NGAL), serum creatinine, and blood urea nitrogen (BUN) levels were tested by enzyme-linked immunosorbent assay. hUCMSCs and exosomes were identified

resultsKIM-1, NGAL, serum creatinine, and BUN levels were increased and miR-21-5p expression was inhibited in AKI after cardiac surgery. In AKI after cardiac surgery, hUCMSCs-Exos inhibited apoptosis and pyroptosis and promoted viability

conclusionshUCMSCs-Exos protect against AKI by enhancing miR-21-5p/TEAD1 binding

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresDNA-Binding ProteinsExosomesMesenchymal Stem CellsMicroRNAsNuclear ProteinsTranscription FactorsAnimalsApoptosisDisease Models, AnimalHepatitis A Virus Cellular Receptor 1HumansMaleMiceTEA Domain Transcription FactorsDNA-Binding ProteinsHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1MicroRNAsMIRN21 microRNA, humanNuclear ProteinsTEA Domain Transcription FactorsTranscription Factorsacute kidney injuryexosomesHuman umbilical cord mesenchymal stem cellsmiR-21-5pTEA domain family member 1

Identifiers

PMID40775738
PMCPMC12333020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.