Evidence map›Paper›PMID 40775548›Full record

ReviewNature cancer2025

Nanotechnology for immuno-oncology.

Adam J Grippin, DaeYong Lee, Eileen E Parkes, Wen Jiang, Betty Y S Kim

Abstract readReview
In one paragraph

Review in Nature cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Antibody-Empowered Nanomedicine for Precise Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  12. Review
  13. Review
  14. Glioma Cell Membrane-Coated CaCOInternational journal of nanomedicine · 2026
    Article
  15. The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adam J Grippin *Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8076-4240
DaeYong Lee *Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Eileen E ParkesDepartment of Oncology, Oxford University, Oxford, UK.ORCID http://orcid.org/0000-0002-7855-3698
Wen JiangDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. wjiang4@mdanderson.org.ORCID http://orcid.org/0000-0001-9154-633X
Betty Y S KimDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. bykim@mdanderson.org.ORCID http://orcid.org/0000-0001-6890-8355

Funding

Interdisciplinary Translational Pre/Postdoctoral Program in Cancer NanotechnologyT32CA196561 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Gang Bao, Konstantin V Sokolov · 2015 to 2026
$3.0M
Engineering In Vivo Chimeric Antigen Receptor Macrophages (CARMs) using mRNA-exosomes for Cancer ImmunotherapyR01CA284108 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JIANG, WEN, KIM, BETTY · 2023 to 2025
$2.2M
Therapeutic targeting of multiple glioblastoma phagocytosis checkpoints using a novel bispecific antibodyR01NS117828 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JIANG, WEN · 2021 to 2025
$2.2M
Engineering mRNA encapsulated extracellular vesicles for in vivo chimeric antigen receptor macrophage therapy for glioblastomaR01CA291876 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Wen Jiang, Betty Kim · 2024 to 2026
$1.9M
NCI NIH HHS R01 CA284108NCI NIH HHS R01 CA291876NCI NIH HHS T32 CA196561NINDS NIH HHS R01 NS117828
6 · The paper itself

Abstract

Although the first generation of cancer immunotherapeutics produced unprecedented improvements in clinical outcomes for individuals with cancer, novel strategies to increase treatment specificity, delivery efficiency and pharmacokinetics are still needed. In this Review, we describe the potential advantages and current limitations of nanomaterials for cancer immunotherapy and highlight rational uses of nanosystems to generate potent and durable antitumor immune responses. We close with a review of the current state of clinical development of nanomedicine for cancer immunotherapy.

Indexed as

ImmunotherapyMedical OncologyNanomedicineNanotechnologyNeoplasmsAnimalsHumansNanoparticlesNanostructures

Identifiers

PMID40775548
PMCPMC12412309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.