Evidence map›Paper›PMID 40775535›Full record

ArticleActa pharmacologica Sinica2026

Galangin, a novel Kv7 potassium channel opener, exerts potent antinociceptive effects in multiple chronic pain mouse models.

Bo Yang, Hui Liu, Wen-Jing Zhao, Jia-Rui Ma, Zi-Shuo Kang, Yu-Jie Zhang, Yu-Lin Gu, Xiao-Ke Li, Zeng-Wei Mao, Rui-Feng Cao and 3 more

Abstract read
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In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bo Yang *The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Hui Liu *The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Wen-Jing ZhaoThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Jia-Rui MaThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Zi-Shuo KangThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yu-Jie ZhangThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Yu-Lin GuThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Xiao-Ke LiThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Zeng-Wei MaoThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
Rui-Feng CaoDepartment of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
Ya-Ling WangDepartment of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
Han LiDepartment of Orthopaedic Surgery, Institute of Biomechanical Science and Biomechanical Key Laboratory of Hebei Province, Third Hospital of Hebei Medical University, Shijiazhuang, 050061, China. 38400388@hebmu.edu.cn.
Fan ZhangThe Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Vascular Biology of Hebei Province, Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China. zhangfan86@hebmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The activation of voltage-gated potassium Kv7/M channels is an attractive therapeutic strategy for chronic pain. Galangin, the principal active component of the medicinal herb Alpinia officinarum Hance, has exhibited analgesic effects in mice. In this study, we investigated the antinociceptive effects of galangin in the treatment of various types of chronic pain and the underlying mechanisms. Using whole-cell recordings of CHO cells expressing Kv7.2/Kv7.3 channels, we showed that galangin enhanced Kv7.2/Kv7.3 currents in a concentration-dependent manner, with an EC

Indexed as

AnalgesicsChronic PainFlavonoidsAnimalsCHO CellsCricetinaeCricetulusDisease Models, AnimalDose-Response Relationship, DrugKCNQ2 Potassium ChannelMaleMiceAnalgesicsFlavonoidsgalanginKCNQ2 Potassium Channelchronic painDRG neuronsgalanginKv7/M channelneuronal excitability

Identifiers

PMID40775535
PMCPMC12811617

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.