ArticleScientific reports2025
Complementary MR measures of white matter and their relation to cardiovascular health and cognition.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- DTI-ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi-Modal MRI.Human brain mapping · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Longitudinal myelin MR imaging in patients with multiple sclerosis: a narrative review.Journal of neurology · 2026Review
- Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter.Imaging neuroscience (Cambridge, Mass.)Article
- Intracranial volume: To adjust or not to adjust? It is not a matter of if, but how.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The microstructural and macrostructural integrity of white matter (WM) underpins efficient brain function, and is known to decline with age and vascular burden. Key aspects of WM health include axonal fibre density, myelination, free-water content, and the presence of tissue damage or lesions. Magnetic Resonance Imaging (MRI) offers multiple complementary sequences to non-invasively estimate these properties in vivo. For example, diffusion-weighted imaging (DWI) provides sensitive measures of microstructure, while T1-weighted and T2-weighted MRI can estimate total WM volume and hyper-intensities, and magnetisation transfer imaging (MT) and T1:T2 ratios can indicate myelin content. In this study, we leveraged all of these MRI-derived measures in a large population-based cohort (Cam-CAN) to identify latent WM factors and test how these factors relate to cardiovascular health and cognitive performance. Among 11 commonly-used WM metrics [Fractional Anisotropy (FA); Mean Signal Diffusion (MSD); Mean Signal Kurtosis (MSK); Neurite Density Index (NDI); fibre Orientation Dispersion Index (ODI); Free water volume faction (F
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.