Evidence map›Paper›PMID 40775463›Full record

ArticleScientific reports2025

Exploring the clinical value of concept-based AI explanations in gastrointestinal disease detection.

Andrea M Storås, Maximilian Dreyer, Frederik Pahde, Sebastian Lapuschkin, Wojciech Samek, Pål Halvorsen, Thomas de Lange, Yuichi Mori, Alexander Hann, Tyler M Berzin and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea M StoråsDepartment of Holistic Systems, SimulaMet, Oslo, Norway. andreatheomine@gmail.com.
Maximilian DreyerExplainable Artificial Intelligence Group, Fraunhofer Heinrich Hertz Institute, Berlin, Germany.
Frederik PahdeExplainable Artificial Intelligence Group, Fraunhofer Heinrich Hertz Institute, Berlin, Germany.
Sebastian LapuschkinExplainable Artificial Intelligence Group, Fraunhofer Heinrich Hertz Institute, Berlin, Germany.
Wojciech SamekExplainable Artificial Intelligence Group, Fraunhofer Heinrich Hertz Institute, Berlin, Germany.
Pål HalvorsenDepartment of Holistic Systems, SimulaMet, Oslo, Norway.
Thomas de LangeDepartment of Medicine and Emergencies - Mölndal, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Yuichi MoriClinical Effectiveness Research Group, University of Oslo and Oslo University Hospital, Oslo, Norway.
Alexander HannInterventional and Experimental Endoscopy (InExEn), Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Tyler M BerzinCenter for Advanced Endoscopy, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States.
Sravanthi ParasaDepartment of Gastroenterology, Providence Swedish, Seattle, Washington, United States.
Michael A RieglerDepartment of Holistic Systems, SimulaMet, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex artificial intelligence models, like deep neural networks, have shown exceptional capabilities to detect early-stage polyps and tumors in the gastrointestinal tract. These technologies are already beginning to assist gastroenterologists in the endoscopy suite. To understand how these complex models work and their limitations, model explanations can be useful. Moreover, medical doctors specialized in gastroenterology can provide valuable feedback on the model explanations. This study explores three different explainable artificial intelligence methods for explaining a deep neural network detecting gastrointestinal abnormalities. The model explanations are presented to gastroenterologists. Furthermore, the clinical applicability of the explanation methods from the healthcare personnel's perspective is discussed. Our findings indicate that the explanation methods are not meeting the requirements for clinical use, but that they can provide valuable information to researchers and model developers. Higher quality datasets and careful considerations regarding how the explanations are presented might lead to solutions that are more welcome in the clinic.

Indexed as

Deep LearningEndoscopy, GastrointestinalGastrointestinal DiseasesImage Interpretation, Computer-AssistedDatasets as TopicGastroenterologyGastrointestinal TractHumansConcept explanationsDeep learningExplainable artificial intelligenceGastroenterology

Identifiers

PMID40775463
PMCPMC12332007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.