Evidence map›Paper›PMID 40775454›Full record

ArticleMolecular biology reports2025

Atractylenolide III alleviates amyloid-β-induced cognitive impairments in mice.

Hao Yuan, Lei Xia, Junjie Li, Chunfang Dai, Xiaohuan Li, Boqing Xu, Mengtong Xue, Xiuyu Shi, Bin Wu, Zhifang Dong and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao YuanGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Lei XiaGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Junjie LiGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Chunfang DaiGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Xiaohuan LiGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Boqing XuGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Mengtong XueGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Xiuyu ShiGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Bin WuGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Zhifang DongGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. zfdong@aliyun.com.
Yayan PangGrowth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. 405033751@qq.com.

Funding

Chongqing Education Commission Graduate Student Innovation Project CYB240206Chongqing Education Commission Youth Project KJQN202400423Guangzhou Municipal Science and Technology Project 202201011094Innovation Team Project of Guangdong General Colleges and Universities (Natural Science) 2024KCXTD016National Natural Science Foundation of China 32371030the CQMU Program for Youth Innovation in Future Medicine W0044the Natural Science Foundation of Chongqing CSTB2024NSCQ-LZX0008
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition, which triggers oxidative stress and neuronal damage. Atractylenolide III (AT-III), a plant-derived monomer with antioxidant properties, has shown promise but its neuroprotective effects in AD remain unclear.

methodsWe established an AD mice model via intracerebroventricular Aβ₁₋₄₂ injection and evaluated AT-III's neuroprotective effects using behavioral tests, electrophysiological recordings, Western blot, and ELISA. Additionally, we assessed AT-III's protective effects against hydrogen peroxide (H

resultsAT-III mitigated cognitive and long-term potentiation (LTP) deficits induced by Aβ

conclusionsThese results suggest that AT-III may exert neuroprotective effects through antioxidant properties, thereby ameliorating cognitive impairment induced by Aβ

Indexed as

Amyloid beta-PeptidesCognitive DysfunctionLactonesSesquiterpenesAlzheimer DiseaseAnimalsAntioxidantsDisease Models, AnimalHeme Oxygenase-1Hydrogen PeroxideLong-Term PotentiationMaleMiceNeuroprotective AgentsNF-E2-Related Factor 2Oxidative StressAmyloid beta-Peptidesamyloid beta-protein (1-42)Antioxidantsatractylenolide IIIHeme Oxygenase-1Hydrogen PeroxideLactonesNeuroprotective AgentsNfe2l2 protein, mouseNF-E2-Related Factor 2Peptide FragmentsSesquiterpenesAlzheimer’s diseaseAnti-oxidative stressAtractylenolide IIINrf2

Identifiers

PMID40775454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.