Evidence map›Paper›PMID 40775430›Full record

ArticleScientific reports2025

Degradation kinetics of Andrographolide in aqueous solution, product identification and biological activity evaluation.

Wuttichai Jaidee, Narawadee Rujanapun, Kulawadee Malee, Suchada Chaisawadi, Panupong Puttarak, Poonsit Hiransai, Geoffrey A Cordell, Satyajit D Sarker, Lutfun Nahar, Rawiwan Charoensup

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The sambiloto (Journal of advanced veterinary and animal research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wuttichai JaideeMedicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
Narawadee RujanapunMedicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
Kulawadee MaleeMedicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, Chiang Rai, 57100, Thailand.
Suchada ChaisawadiPilot Plant Development and Training Institute, King Mongkut's University of Technology Thonburi, Bangkok, 10150, Thailand.
Panupong PuttarakPhytomedicine and Pharmaceutical Biotechnology Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkhla University, Hat-Yai, Songkhla, 90110, Thailand.
Poonsit HiransaiCenter of Excellence in Marijuana, Hemp, and Kratom, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Geoffrey A CordellNatural Products Inc., Evanston, IL, 60201, USA.
Satyajit D SarkerCentre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Lutfun NaharLaboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Šlechtitelů 27, 78371, Olomouc, Czech Republic.
Rawiwan CharoensupMedicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, Chiang Rai, 57100, Thailand. rawiwan.cha@mfu.ac.th.

Funding

Basic Research Fund 2023 662A17029National Research Council of Thailand N34E660176Permanent Secretary of the Ministry of Higher Education, Science, Research, and Innovation F01-673R17-135The Thailand Science Research and Innovation Fund DBG6280007
6 · The paper itself

Abstract

Andrographolide (1) is a labdane-type diterpene lactone and the major bioactive metabolite (2.39%) in the leaves of Andrographis paniculata (Acanthaceae). To further explore its stability, the thermal degradation kinetics of compound 1 at pH 2.0, pH 6.0, and pH 8.0 were modeled at three temperatures within 50-85 °C. The activation energy (E

Indexed as

DiterpenesAndrographisAnimalsAnti-Inflammatory AgentsDrug StabilityHumansHydrogen-Ion ConcentrationKineticsMicePlant LeavesTemperatureWaterandrographolideAnti-Inflammatory AgentsDiterpenesWaterAndrographolideArrhenius equationCytotoxicityDegradationNO productionpH dependencyProduct characterization

Identifiers

PMID40775430
PMCPMC12331895

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.