Evidence map›Paper›PMID 40775419›Full record

ArticleScientific reports2025

Effects of natural Lithium and Lithium isotopes on voltage gated sodium channel activity in SH-SY5Y and IPSC derived cortical neurons.

Irina Bukhteeva, James D Livingstone, Kartar Singh, Evgeny V Pavlov, Michael A Beazely, Michel J P Gingras, Zoya Leonenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Irina BukhteevaDepartment of Physics and Astronomy, University of Waterloo, Waterloo, ON, N2L-3G1, Canada.
James D LivingstoneSchool of Pharmacy, University of Waterloo, Kitchener, ON, N2G-1C5, Canada.
Kartar SinghSchool of Pharmacy, University of Waterloo, Kitchener, ON, N2G-1C5, Canada.
Evgeny V PavlovDepartment of Molecular Pathobiology, New York University, New York, 10010, NY, USA.
Michael A BeazelySchool of Pharmacy, University of Waterloo, Kitchener, ON, N2G-1C5, Canada.
Michel J P GingrasDepartment of Physics and Astronomy, University of Waterloo, Waterloo, ON, N2L-3G1, Canada.
Zoya LeonenkoDepartment of Physics and Astronomy, University of Waterloo, Waterloo, ON, N2L-3G1, Canada. zleonenk@uwaterloo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although lithium (Li) is a widely used treatment for bipolar disorder, its exact mechanisms of action remain elusive. Research has shown that the two stable Li isotopes, which differ in their mass and nuclear spin, can induce distinct effects in both in vivo and in vitro studies. Since sodium (Na

Indexed as

Cerebral CortexInduced Pluripotent Stem CellsLithiumNeuronsVoltage-Gated Sodium ChannelsCell Line, TumorHumansIsotopesPatch-Clamp TechniquesSodiumIsotopesLithiumSodiumVoltage-Gated Sodium ChannelsIPSC-derived cortical neuronsLithium isotopesMammalian sodium channelsPatch-clampSH-SY5Y

Identifiers

PMID40775419
PMCPMC12332186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.