Evidence map›Paper›PMID 40775396›Full record

ReviewAntonie van Leeuwenhoek2025

Utilization of probiotics against virulence factors of Staphylococcus aureus in bovine mastitis.

Muhammad Yousif, Fei Liao, Ziyao Tang, Feng Yang, Rabia Tahir, Zahid Iqbal Rajput, Muhammad Farooque Hassan, Kasim Sakran Abass, Yanchun Hu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Antonie van Leeuwenhoek, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muhammad YousifKey Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Fei LiaoKey Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Ziyao TangKey Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Feng YangKey Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Rabia TahirCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Zahid Iqbal RajputShaheed Benazir Bhutto University of Veterinary and Animal Sciences, Sakrand, 67210, Sindh, Pakistan.
Muhammad Farooque HassanShaheed Benazir Bhutto University of Veterinary and Animal Sciences, Sakrand, 67210, Sindh, Pakistan.
Kasim Sakran AbassDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Kirkuk, Kirkuk, 36001, Iraq.
Yanchun HuKey Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China. hychun114@163.com.

Funding

Science and Technology Department of Sichuan Province 2020YFS0337
6 · The paper itself

Abstract

Bovine mastitis is an important economic and public health issue of the milk sector which leads to reduction in milk-production, quality, and increased culling rates. The main causative is Staphylococcus aureus because this microorganism has ability to produce the virulence factors like hemolysins. However, these factors enhance defense against host immune system and produce antibiotic resistance because the antibiotic agents are frequently used and also the antibiotic residues may be remained in the milk which is a major publish health concern. This issue can be counteracted by alternative such as probiotics. Therefore, this review focuses on the utilization of probiotics against Staphylococcus aureus virulence factors and product the mammary glands from commensal and colonizing to disease. it highlights how probiotics interfere against pathogenesis such as; biofilm production, hemolysins, adhesion, invasion into mammary epithelial cells, and quorum-sensing signaling, all of which are pivotal for colonization. Ultimately, probiotics proves advantageous in treating and preventing bovine mastitis, potentially contributing to an extended disease-free period and reduce the frequent use of antibiotics. The aims of this study are to systematically summarize the mechanisms by which probiotics counteract Staphylococcus aureus virulence factors, evaluate the efficacy of probiotics in the prevention and treatment of bovine mastitis and provide a theoretical basis for the practical application of probiotics as an alternative to antibiotics in the dairy industry.

Indexed as

Mastitis, BovineProbioticsStaphylococcal InfectionsStaphylococcus aureusVirulence FactorsAnimalsBiofilmsCattleFemaleMilkVirulence FactorsBovine mastitisHemolysin toxinsProbioticsStaphylococcus aureusVirulence

Identifiers

PMID40775396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.