ArticleMicrobiome2025
Sulfoquinovose is exclusively metabolized by the gut microbiota and degraded differently in mice and humans.
Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay.Gut microbes · 2026Review
- gutSMASH 2.0: Extended Identification of Primary Metabolic Gene Clusters From the Human Gut Microbiota.Journal of molecular biology · 2026Article
- Effects of selection on production parameters and intestinal microbiota in heritage and modern broiler chickens.Journal of animal science and biotechnology · 2026Article
- Microbiome-Responsive Hydrogels: From Biological Cues to Smart Biomaterials.Pharmaceutics · 2026Review
- Studying organosulfonate metabolism in southern Russia chernozem soil microbial community: ubiquity of the desulfonation pathways and possible mixotrophy in common soil heterotrophs.Archives of microbiology · 2026Article
- Widespread marine and freshwater distributions of active sulfoquinovose-degrading bacteria.The ISME journal · 2026Article
- Sulfoquinovose degradation by cow rumen microbiota.The ISME journal · 2026Article
- Advances in microbial sulfoquinovose catabolism.Frontiers in microbiology · 2026Review
- Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSulfoquinovose (SQ) is a green-diet-derived sulfonated glucose and a selective substrate for a limited number of human gut bacteria. Complete anaerobic SQ degradation via interspecies metabolite transfer to sulfonate-respiring bacteria produces hydrogen sulfide, which has dose- and context-dependent health effects. Here, we studied potential SQ degradation by the mammalian host and the impact of SQ supplementation on human and murine gut microbiota diversity and metabolism.
results
conclusionsOur findings suggest that SQ is solely a nutrient for the gut microbiota and not for mice and humans, emphasizing its potential as a prebiotic. SQ degradation by the microbiota of conventional laboratory mice differs from the human gut microbiota by absence of DHPS degradation activity. Hence, the microbiota of conventional laboratory mice does not fully represent the SQ metabolism in humans, indicating the need for alternative model systems to assess the impact of SQ on human health. This study advances our understanding of how individual dietary compounds shape the microbial community structure and metabolism in the gut and thereby potentially influence host health. Video Abstract.
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Registered trials
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