ArticleReproductive health2025
Sleep behaviors and time-to-pregnancy: results from a Guangzhou City cohort.
Article in Reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Preconception Folate Status, Dietary Intake, Supplementation, and Time to Pregnancy Among Women in a Premarital Health Examination Cohort.Nutrients · 2026Article
- Correlation between thyroid hormone levels and cognitive dysfunction in older patients with subclinical hypothyroidism : A matched groups retrospective study.Wiener klinische Wochenschrift · 2026Article
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4 authors.
Funding
Abstract
introductionFertility outcomes are increasingly influenced by modern lifestyle factors, including sleep behaviors. However, the relationship between sleep and time to pregnancy (TTP) is underexplored.
methodsWe conducted a prospective cohort study of 1,684 couples in Guangzhou, China. Sleep behaviors were assessed via structured interviews. Cox proportional hazards models were used to estimate fecundability ratios (FRs), adjusting for potential confounders. Sleep-wake regularity was assessed for all women. Among those with regular patterns (n = 1506), we further analyzed sleep duration, bedtime, perceived sleep sufficiency, and insomnia.
resultsAmong all participants, 178 (10.6%) had irregular sleep. Time-varying models revealed that compared to regular sleepers, irregular sleepers exhibited a decreasing fecundability ratio (FR < 1) after approximately 2.6 months of attempting pregnancy, with the association becoming statistically significant after 4.1 months. In women with regular sleep, longer sleep duration was associated with higher fecundability (adjusted FR = 1.18, 95% CI: 1.09-1.27; p < 0.001). Spline analysis indicated a linear increase in fecundability with sleep durations exceeding 7.5 h. Perceived insufficient sleep was linked to reduced fecundability (adjusted FR = 0.62, 95% CI: 0.48-0.81; p < 0.001), while later bedtime was associated with lower fecundability (adjusted FR = 0.91, 95% CI: 0.84-0.98; p = 0.045). Insomnia showed no significant effect (adjusted FR = 0.86, 95% CI: 0.67-1.11, p = 0.241).
conclusionsIrregular sleep patterns may reduce fecundability over time. Among women with regular sleep, longer duration, earlier bedtime, and sufficient perceived sleep were associated with improved reproductive potential. Sleep optimization could be a modifiable behavioral target to enhance fertility.
trial registrationChiCTR2300068809 registered 1/3/2023.
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