ArticleBMC cancer2025
LncRNA SNHG15 targets miR-200a-3p affects the proliferation, apoptosis, migration, and invasion of cervical cancer cells.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Long non-coding RNAs: a new hope for the cervical cancer staging.Molecular biology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundCervical cancer is a major challenge facing women's health worldwide. In China, its incidence and mortality rate rank first among female reproductive tract malignancies. SNHG15 has been found and proven to have important functions in many cancers. Related studies have shown that miR-200a-3p plays an important role in tumor development. However, there is little research on how the two are involved in the progression of cervical cancer cells and their potential regulatory systems.
methodsqRT-PCR was used to detect the expression of LncRNA SNHG15 in human cervical immortalized squamous cells (Ect1/E6E7) and human cervical cancer cell lines (SiHa, HeLa, Caski, C-33 A). Cervical cancer HeLa and SiHa cells were used as the research objects and were divided into NC, GV493-negative group, SNHG15-shRNA group, empty vector group, and SNHG15-OERNA group. The expression levels of LncRNA SNHG15 and miR-200a-3p in cells were detected by qRT-PCR. CCK8 was used to detect cell proliferation, cell migration and invasion ability, and dual luciferase activity was used to analyze the targeted binding of LncRNA SNHG15 and miR-200a-3p.
resultsCompared with human cervical immortalized squamous cells (Ect1/E6E7), the expression level of LncRNA SNHG15 in human cervical cancer cell lines SiHa, HeLa and C-33 A was increased(P<0.05). Cervical cancer cells HeLa and SiHa with more significant differences were selected for subsequent studies. Overexpression of LncRNA SNHG15 or low expression of miR-200a-3p promoted cell proliferation, migration and invasion (P < 0.05).
conclusionHigh expression of SNHG15 progression cervical cancer cell proliferation, migration, and invasion by targeting the miR-200a-3p gene.
trial registrationTrial registration: DRKS, ISRCTNDRKS00035987. Registration on 17 February 2025-Retrospectively registered, https://drks.de/register/de/trial/DRKS00035987.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.