Evidence map›Paper›PMID 40775259›Full record

ArticleScientific reports2025

Gut microbiota maturation and early behavioral and cognitive development.

Ziliang Zhu, Yue Yang, Tinu M Samuel, Tengfei Li, Weiyan Yin, Brittany R Howell, Seoyoon Cho, Heather C Hazlett, Jed T Elison, Hongtu Zhu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ziliang ZhuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yue YangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tinu M SamuelNestlé Product Technology Center-Nutrition, Société Des Produits Nestlé S.A. Vevey, Vevey, Switzerland.
Tengfei LiDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Weiyan YinBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, North Carolina, Chapel Hill, CB#7513, USA.
Brittany R HowellDepartment of Human Development and Family Science, Fralin Biomedical Research Institute at VTC, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.
Seoyoon ChoDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Heather C HazlettDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jed T ElisonInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Hongtu ZhuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Norbert SprengerNestlé Institute of Health Sciences, Société Des Produits Nestlé SA, Lausanne, Switzerland.
Weili LinDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Weili_lin@med.unc.edu.

Funding

INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32MH015755 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Megan R Gunnar · 1985 to 2026
$5.9M
UNC/UMN Baby Connectome ProjectU01MH110274 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELISON, JED THOMAS, GILMORE, JOHN HORACE · 2016 to 2019
$4.5M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Analysis of Big Data Squared in Biomedical StudiesR01MH116527 · NIMH · YALE UNIVERSITY · PI ZHANG, HEPING · 2018 to 2022
$2.3M
NIH HHS R01MH086633NIH HHS R01MH116527NIMH NIH HHS MH015755NIMH NIH HHS R01 MH086633NIMH NIH HHS R01 MH116527NIMH NIH HHS T32 MH015755NIMH NIH HHS U01 MH110274NIMH NIH HHS U01MH110274
6 · The paper itself

Abstract

The presence of gut microbiota-brain-axis has been widely reported. However, few studies have focused on uncovering the potential associations during a time-period that our brain and gut microbiota undergo rapid maturation. We evaluated the potential associations between characteristics of gut microbiota and cognition and temperament using an accelerated longitudinal design in typically developing children over 0-3 years of age. Specifically, we extracted gut microbiota characteristics at three scale levels: diversity measures, microbial networks, and subject-wise longitudinal trajectory features, shedding light on how associations between cognition/temperament and gut microbiota may differ at global (diversity), ecological (microbial networks) and subject-wise levels. Our findings illustrated that associations between gut microbiota and temperament/cognition varied with the analytical approaches and highlighted differential gut microbial features in association with cognition and temperament traits-diversity measures and microbial networks largely with cognition while subject-wise trajectories with temperament. In addition, Ruminococcus bromii exhibited significant associations with cognitions spanning over multiple subdomains. Finally, the associations of gut microbiota with temperament and cognition converge on the potential interplay of language ability and social behaviors and highlight the importance of age-appropriate gut microbiota on early cognition/temperament development.

Indexed as

Child DevelopmentCognitionGastrointestinal MicrobiomeChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleTemperament

Identifiers

PMID40775259
PMCPMC12332070

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.