Evidence map›Paper›PMID 40775192›Full record

SynthesisAesthetic plastic surgery2026

Renal Complications Associated with Silicone, Methacrylate, and Oil-Based Fillers: A Systematic Review.

Agustin N Posso, Gabriel Cojuc-Konigsberg, Audrey Mustoe, Morvarid Mehdizadeh, Jose Foppiani, Maria J Escobar-Domingo, Samuel J Lin, Bernard T Lee

Abstract readSystematic ReviewReview
PubMed Publisher
In one paragraph

Synthesis in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Agustin N PossoDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Gabriel Cojuc-KonigsbergDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Audrey MustoeDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Morvarid MehdizadehDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Jose FoppianiDivision of Plastic and Reconstructive Surgery, University of Minnesota, Minneapolis, MN, USA.
Maria J Escobar-DomingoDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Samuel J LinDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Bernard T LeeDivision of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. blee3@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFiller injections are one of the most common minimally invasive cosmetic procedures. Some of the related adverse effects remain unexplored, such as kidney-related complications. This systematic review aims to summarize the cases of patients who developed kidney disease after filler injections.

methodsThe study protocol followed the PRISMA guidelines. Multiple online databases were used in this review. Eligible studies included cases of patients who developed any kidney-related complication after filler injections. A two-stage screening process was conducted for study selection. Data extraction focused primarily on kidney complications.

resultsTwenty-nine patients were identified, from 18 case reports and 4 case series. The most frequently injected anatomical site was the buttocks (72.41%, n=21). The three most identified fillers included silicone (51.72%, n=15), methacrylate (31.03%, n=9), and oil (17.24%, n=5). Notably, the status of the practitioner who administered the injections was reported as a non-medical professional in six articles. The most common reported kidney-related complication was chronic kidney disease (CKD), affecting 55.17% (n=16) of patients. Most patients received treatment through hydration (68.97%, n=20) and steroids (68.97%, n=20), while surgery was performed in 20.69% (n=6) of cases. After the renal complication, 37.93% (n=11) patients achieved remission, 20.69% (n=6) patients developed CKD, and 10.34% (n=3) patients died.

conclusionsThis study described 29 patients who developed renal complications after filler injections. The prevalence of unlicensed or unidentified practitioners performing these procedures could increase the risk of severe outcomes. This underscores the need for stringent regulations and education. NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Cosmetic TechniquesDermal FillersKidney DiseasesSiliconesAdultEstheticsFemaleHumansMaleMiddle AgedRisk AssessmentDermal FillersSiliconesCosmetic injectionsFillersKidney diseaseRenal complicationsSystematic review

Identifiers

PMID40775192

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.