Evidence map›Paper›PMID 40775176›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025

Altered cell length in deletion mutants of the different divIVA genes in Rhodococcus erythropolis PR4.

Shabnam Parwin, Preeti Srivastava

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Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

2 authors.

Shabnam ParwinDepartment of Biochemical Engineering & Biotechnology, Indian Institute of Technology, Delhi, New Delhi, India.
Preeti SrivastavaDepartment of Biochemical Engineering & Biotechnology, Indian Institute of Technology, Delhi, New Delhi, India. preeti@dbeb.iitd.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlike other Actinobacteria, Rhodococcus erythropolis PR4 contains three different copies of divIVA genes. The three divIVA genes show about 22-38% similarity with each other. Deletion mutants of the divIVA genes resulted in altered morphology: elongated cells in △divIVA-2 and short rod-shaped cells in △divIVA-1 and △divIVA-3. The expression of the divIVA-2 gene was found to be higher as compared to the divIVA-1 and divIVA-3 genes in wild-type cells. The subcellular localisation studies revealed that the three different DivIVA proteins are spatially present at different regions of cell space. Our results suggest that an interplay of the three DivIVA proteins plays a role in cell shape maintenance in R. erythropolis PR4. Bioinformatics analysis and interactome study show that amongst the three copies of divIVA genes, the second copy, i.e., divIVA-2 gene, might have a more governing function in the cell division process as compared to the other two copies.

Indexed as

Bacterial ProteinsCell Cycle ProteinsGene DeletionRhodococcusCell DivisionGene Expression Regulation, BacterialBacterial ProteinsCell Cycle ProteinsCell divisionCell lengthFluorescence microscopyGene expressionSeptation

Identifiers

PMID40775176

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.