ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Prevalence and associated factors of cognitive frailty in older patients with lung cancer undergoing chemotherapy: a cross-sectional study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors for frailty in older adults with cancer: a systematic review.BMC geriatrics · 2026Pooled it
- Prevalence and associated factors of cognitive frailty in older adults with heart failure: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Frailty Trajectories and Their Predictors in Chinese Empty-Nest Older Adults: An 8-Year Longitudinal Study.Healthcare (Basel, Switzerland) · 2026Article
- Prediction model for postoperative delirium risk in elderly hypertensive patients: machine learning-based development and validation.Frontiers in psychiatry · 2026Article
- Influencing factors of cognitive frailty in older patients with esophageal cancer undergoing chemotherapy: a mixed-methods study.Frontiers in oncology · 2026Article
- The effectiveness of the AI-based RehabLung mobile rehabilitation system on cardiopulmonary function and user satisfaction in lung cancer patients undergoing thoracic surgery: a protocol for a two-arm randomized clinical trial.Therapeutic advances in respiratory diseaseArticle
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Abstract
purposeTo examine the prevalence of cognitive frailty and identify its influencing factors among in older patients with lung cancer undergoing chemotherapy.
methodsA cross-sectional study was conducted between January and August 2024 among 304 older patients with lung cancer undergoing chemotherapy at a tertiary hospital in Chengdu, China. Data were collected using a general information questionnaire, the FRAIL Scale, the Mini-Mental State Examination (MMSE), the Hospital Anxiety and Depression Scale (HADS), and the Nutritional Risk Screening 2002 (NRS 2002). Binary logistic regression was performed to identify independent risk factors associated with cognitive frailty.
resultsA total of 304 older patients with lung cancer undergoing chemotherapy finished the investigation. The prevalence of cognitive frailty was 26.3% (80/304). In the initial phase of analysis, 13 independent variables were selected from 23 candidate variables through univariate analysis. Subsequent binary logistic regression analysis revealed that age, monthly household income per capita, employment status, health insurance type, cancer stage, anxiety, depression, nutritional risk, and daily exercise duration were independently associated with cognitive frailty.
conclusionThe prevalence of cognitive frailty is high among older patients with lung cancer undergoing chemotherapy and is influenced by multiple factors. Therefore, screening for cognitive frailty should be considered in clinical practice, with particular focus on elderly patients, those with low income, and those in advanced stages of the disease. It is crucial to take into account the patients' physiological, psychological, and behavioral factors when designing and implementing multimodal, individualized intervention strategies, aiming to effectively prevent and alleviate cognitive frailty.
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