Evidence map›Paper›PMID 40775084›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Femur geometry influences atypical femoral fracture location.

Olivia L Bruce, Ifaz T Haider, Angela M Cheung, Lianne Tile, Robert Bleakney, Judy Scher, W Brent Edwards

Abstract read
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olivia L BruceDepartment of Biomedical Engineering, Schulich School of Engineering, University of Calgary, 2500 University Dr NW, Calgary, AB, T2N 1N4, Canada. obruce@stanford.edu.ORCID http://orcid.org/0000-0003-2651-626X
Ifaz T HaiderMcCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, 2500 University Dr NW, Calgary, AB, T2N 1N4, Canada.
Angela M CheungCentre of Excellence in Skeletal Health Assessment, Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Lianne TileOsteoporosis Program, Department of Medicine, University Health Network, Toronto, ON, Canada.
Robert BleakneyCentre of Excellence in Skeletal Health Assessment, Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Judy ScherOsteoporosis Program, Department of Medicine, University Health Network, Toronto, ON, Canada.
W Brent EdwardsDepartment of Biomedical Engineering, Schulich School of Engineering, University of Calgary, 2500 University Dr NW, Calgary, AB, T2N 1N4, Canada.

Funding

Canada Research Chairs MusculoskeletalCanada Research Chairs Postmenopausal HealthCanada Research Chairs Tier 1CIHR 392011Natural Sciences and Engineering Research Council of Canada CGS-D2019Osteoporosis Canada Tim Murray Short Term Training Award
6 · The paper itself

Abstract

Bone geometry is thought to be an important factor in the development of atypical femoral fracture. Our three-dimensional analysis of whole-femur geometry indicates that lateral bowing influences fracture location. Lateral bowing may indeed play a role in AFF pathophysiology. INTRODUCTION/PURPOSE: Atypical femoral fracture (AFF) is a low-energy fracture of the diaphyseal, distal femoral, or subtrochanteric regions. Lower limb geometry may be an important factor in the development of AFF, but studies to date have been limited to a handful of simple discrete measurements. The purpose of this study was to evaluate variations in whole-bone geometry in patients with AFF and to determine whether geometry variations were associated with AFF location using statistical shape modeling.

methodsComputed tomography scans of fifty-seven AFF patients were used to create a statistical shape model. Principal component scores and discrete measures were compared between patients with subtrochanteric and midshaft AFF.

resultsTwo principal component scores, both characterizing variations in lateral bowing and anteversion, distinguished between fracture location (p ≤ 0.005). Principal component scores indicating greater lateral bowing and less anteversion were moderately correlated with more distal fracture locations (PC 1: r = 0.41, p = 0.001; PC 3: r = 0.48, p < 0.001). Interestingly, anterior bowing was not different between fracture locations.

conclusionsOur three-dimensional analysis of whole femur geometry indicates that lateral bowing influences fracture location and may play a role in AFF pathophysiology.

Indexed as

Femoral FracturesFemurOsteoporotic FracturesAdultAgedAged, 80 and overFemaleHumansImaging, Three-DimensionalMaleMiddle AgedPrincipal Component AnalysisTomography, X-Ray ComputedAntiresorptivesBisphosphonatesBone morphologyOsteoporosisStatistical shape model

Identifiers

PMID40775084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.