Evidence map›Paper›PMID 40775052›Full record

ReviewNature medicine2025

Strengthening Africa's brain health and economic resilience.

Mie Rizig, Connor McLaughlin, Vaibhav A Narayan, Mohamed Salama, Chinedu T Udeh-Momoh, Chido Ratidzai Rwafa-Madzvamutse, Muthoni Gichu, Akin Ojagbemi, Maëlenn Guerchet, Byron Bitanihirwe and 15 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Mie RizigDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK. m.rizig@ucl.ac.uk.ORCID http://orcid.org/0000-0003-2420-4449
Connor McLaughlinDavos Alzheimer's Collaborative, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0001-2572-5935
Vaibhav A NarayanDavos Alzheimer's Collaborative, Philadelphia, PA, USA.
Mohamed SalamaInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Chinedu T Udeh-MomohSchool of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Chido Ratidzai Rwafa-MadzvamutseWorld Health Organization African Region (AFRO), Brazzaville, Congo.
Muthoni GichuDivision of Geriatric Medicine, Ministry of Health, Nairobi, Kenya.
Akin OjagbemiDepartment of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Maëlenn GuerchetInserm U1094, IRD UMR270, University of Limoges, CHU Limoges, EpiMaCT - Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.ORCID http://orcid.org/0000-0002-0470-5556
Byron BitanihirweScience for Africa Foundation, Nairobi, Kenya.
Lingani Mbakile-MahlanzaUniversity of Botswana, Faculty of Social Sciences, Department of Psychology, Gaborone, Botswana.ORCID http://orcid.org/0000-0002-1285-3276
Razak GyasiAfrican Population and Health Research Centre, Nairobi, Kenya.
Cyprian M MostertBrain and Mind Institute, Aga Khan University, Nairobi, Kenya.
Mosab Ali AwadelkareemNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6898-6310
Mouly FallDepartment of Neurology, National Pikine Hospital, Dakar, Senegal.
Alfred K NjamnshiBrain Research Africa Initiative (BRAIN), Geneva, Switzerland.
Rufus AkinyemiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training (IAMRAT), College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID http://orcid.org/0000-0001-5286-428X
Raj KalariaClinical and Translational Research Institute, Newcastle University, Newcastle, UK.
Riadh GouiderDepartment of Neurology, LR18SP03, Clinical Investigation Centre (CIC) 'Neurosciences and Mental Health', Razi University Hospital, Tunis, Tunisia.ORCID http://orcid.org/0000-0001-9615-3797
Drew HolzapfelDavos Alzheimer's Collaborative, Philadelphia, PA, USA.
Zul MeraliBrain and Mind Institute, Aga Khan University, Nairobi, Kenya.
Stephen TollmanSAMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Harris A EyreOffice of Innovation, Center for Health, Baker Institute for Public Policy, Neuro Engineering Initiative, School of Engineering and Computer Science, Department of Psychological Sciences, School of Social Sciences, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0003-4827-8258
Adesola OgunniyiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training (IAMRAT), College of Medicine, University of Ibadan, Ibadan, Nigeria.
George VradenburgDavos Alzheimer's Collaborative, Philadelphia, PA, USA.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Africa stands at a decisive moment in which urgent action is essential to safeguard its brain health and economic stability. While Africa's population remains predominantly young, it is expanding and aging rapidly. This demographic shift is projected to drive a sharp rise in neurodegenerative diseases, including Alzheimer's, with profound health and economic costs-but brain health research, policy, funding and care across the continent remain critically underdeveloped. In this Perspective, we examine key trends in aging and brain health across Africa and introduce the 6 × 5 Plan-a 5-year strategic framework developed through collective multi-stakeholder insights-to address this pressing challenge. The plan targets six high-impact priorities: strengthening advocacy and health literacy, positioning brain health as a socioeconomic driver, breaking down silos of people and data, repurposing local resources, investing in artificial intelligence and digital health, and boosting research funding. To ensure effective implementation and long-term sustainability, the plan will be executed through a pan-African, multisectoral task force. This initiative seeks to accelerate Africa's response to the needs of a changing population and position the continent as a global leader in brain health innovation.

Indexed as

BrainAfricaAgingHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.