ArticleScientific reports2025
In-silico receptor interactions, phytochemical fingerprint and biological activities of Matricaria chamomilla flower extract and the main components.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Unveiling the antidiabetic, anti-inflammatory and anti-hemolytic activities of Raphanus sativus leaves through in-vitro and in-silico studies.Scientific reports · 2026Article
- Investigating the Chemical, Antifungal, and Cytotoxic Properties of Cochlospermum vitifolium Leaves and Stem Bark Extracts.Chemistry & biodiversity · 2026Article
- ADME/drug-likeness and functional properties of Punica granatum seeds supported with molecular docking, GC-MS and LC-MS/MS analysis.Scientific reports · 2026Article
- Correlation analysis of secondary metabolites, metal elements, and anti-BSA denaturation activity in different parts ofFrontiers in plant science · 2026Article
- Advances in Kaempferol: Extraction, Biosynthesis, and Application with Antibacterial Agents.Antibiotics (Basel, Switzerland) · 2025Review
- Chemical profiling by LC-MS/MS and GC-MS and biological activity assessment of different extracts of Portulaca oleracea through in-vitro and in-silico approaches.Scientific reports · 2025Article
- Eco-friendly remediation of Triflumuron-induced stress with Capsella bursa-pastoris extract.Scientific reports · 2025Article
- Identification of active metabolites fromFrontiers in pharmacology · 2025Article
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Abstract
In this study, total phenolic and flavonoid content, quantitative phenolic analysis, in-vivo, in-vitro and in-silico biological activities of Matricaria chamomilla flower extracts collected from Bulancak (Giresun) were investigated. Phenolic content was determined by LC-MS/MS and antioxidant, antibacterial, antifungal, antigenotoxic and anti-inflammatory activities of the extract and the main components were investigated. Caffeic acid, quercetin and kaempferol were detected as major compounds in the flower extract by LC-MS/MS analysis and the detected levels were 165.085 mg/kg, 112.673 mg/kg and 67.417 mg/kg, respectively. The DPPH radical scavenging activity of M. chamomilla flower extract ranged from 12.4 to 81.1%, while superoxide anion inhibition was observed between 10.6 and 65.8%. Even at low doses, the main components, caffeic acid, quercetin and kaempferol, alone show more potent antioxidant activity. Flower extract was effective against both gram-positive, gram-negative bacteria and fungi and exhibited a broad spectrum antimicrobial effect. Three main components showed a lower sidal effect than the flower extract. M. chamomilla flower extract showed significant antigenotoxicity by reducing NaN
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