Evidence map›Paper›PMID 40774990›Full record

ArticleScientific reports2025

No indications of weight gain associated DNA methylation changes in patients with anorexia nervosa.

Luisa Sophie Rajcsanyi, Miriam Kesselmeier, Christopher Schröder, Carolin Schmelting, Triinu Peters, Manuel Föcker, Isabelle Kraft, Jasmin Beygo, Elsa Leitão, Michael Zeschnigk and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Luisa Sophie Rajcsanyi *Section of Molecular Genetics in Mental Disorders, University Hospital Essen, University of Duisburg-Essen, Virchowstr 174, 45147, Essen, Germany. luisa.rajcsanyi@uk-essen.de.
Miriam Kesselmeier *Institute of Medical Statistics, Computer and Data Sciences (IMSID), Jena University Hospital / Friedrich Schiller University Jena, Jena, Germany.
Christopher SchröderInstitute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Carolin SchmeltingDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Triinu PetersSection of Molecular Genetics in Mental Disorders, University Hospital Essen, University of Duisburg-Essen, Virchowstr 174, 45147, Essen, Germany.
Manuel FöckerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany.
Isabelle KraftDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jasmin BeygoInstitute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Elsa LeitãoInstitute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Michael ZeschnigkInstitute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Johanna GiurannaDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Beate Herpertz-DahlmannDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of the RWTH Aachen, Aachen, Germany.
Jochen SeitzDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Martina de ZwaanDepartment of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.
Wolfgang HerzogDepartment of Internal Medicine II, General Internal and Psychosomatic Medicine, University of Heidelberg, Heidelberg, Germany.
Stefan EhrlichTranslational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus Dresden, University of Technology Dresden, Dresden, Germany.
Stephan ZipfelDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Tübingen, Germany.
Katrin GielDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Tübingen, Germany.
Karin EgbertsDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
Roland BurghardtChild and Adolescent Psychiatry Clinic, Oberberg Fachklinik Fasanenkiez Berlin, Berlin, Germany.
Bettina BudeusGenomics and Transcriptomics Facility, University Hospital Essen, Essen, Germany.
Johannes HebebrandDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Bernhard HorsthemkeInstitute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Anke HinneySection of Molecular Genetics in Mental Disorders, University Hospital Essen, University of Duisburg-Essen, Virchowstr 174, 45147, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anorexia nervosa (AN) is a mental disorder marked by a significantly low body weight. Differentially methylated CpG sites have been reported to be involved in body weight regulation. Methylation pattern may change during considerable weight gain by in-patient treatment. Consequently, we aimed to (1) replicate the hypomethylation at the NR1H3 gene locus (identified in our previous epigenome-wide association study) in independent study groups of 189 female patients with AN and 67 healthy-lean female controls, and (2) identify regions associated with large weight gain associated DNA methylation changes in three patients with AN through whole-genome bisulfite sequencing in CD14

Indexed as

Anorexia NervosaDNA MethylationWeight GainAdolescentAdultCase-Control StudiesCpG IslandsEpigenesis, GeneticFemaleHumansYoung Adult

Identifiers

PMID40774990
PMCPMC12331989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.