Evidence map›Paper›PMID 40774947›Full record

ArticleCell death & disease2025

Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation.

Guang-Xi Yang, De-Liang Peng, Lin Chen, Yu Qian, Le He, Xiao-Yan Chen, Wen-Bin Hong, Cai-Ming Wu, Hang-Zi Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guang-Xi YangThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
De-Liang PengThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
Lin ChenThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
Yu QianThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
Le HeThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
Xiao-Yan ChenThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
Wen-Bin HongThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
Cai-Ming WuThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China.
Hang-Zi ChenThe First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, PR China. chenhz@xmu.edu.cn.ORCID http://orcid.org/0000-0002-4827-2182

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32170777National Natural Science Foundation of China (National Science Foundation of China) U23A20450
6 · The paper itself

Abstract

Protein kinase AKT plays a broad role in promoting energy production in nutrient-rich environments. However, its roles under metabolic stress remain elusive. Herein, we demonstrate a dual mechanism for AKT activation during glucose deprivation. On one hand, glucose deprivation leads to increased levels of ADP and NADP

Indexed as

GlucoseMelanomaProto-Oncogene Proteins c-aktCell Line, TumorEnzyme ActivationHumansNADPPhosphatidylinositol 3-KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseReactive Oxygen SpeciesSignal TransductionSyk KinaseGlucoseNADPPDK1 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPyruvate Dehydrogenase Acetyl-Transferring KinaseReactive Oxygen SpeciesSyk KinaseSYK protein, human

Identifiers

PMID40774947
PMCPMC12331947

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.