Evidence map›Paper›PMID 40774922›Full record

ArticleJournal of the American Chemical Society2025

The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation.

Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sydney S SkirbollDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Medha GangopadhyayDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0009-0006-4739-6833
Han N PhanDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Joshua HartsellDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Aditi MudireddyDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Dalton HilovskyDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Paul D SwartzDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Xiaojing LiuDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-4132-3565
Thomas M MakrisDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0001-7927-620X

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
Elucidate Mechanisms of Quinolone Alkaloid Biosynthesis via Iron(II)/2-Oxoglutarate Dependent Enzymes: Diverse, but Controlled ReactivityR01GM125924 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI Yisong Guo · 2018 to 2026
$3.3M
Investigating the involvement of small intestine in metformin's effect on hepatic lipid metabolismR35GM150985 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Xiaojing Liu · 2023 to 2026
$1.6M
Divergence of Carboxylate-Bridged Diiron Enzymes for Natural Product BiosynthesisR01GM135315 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MAKRIS, THOMAS M · 2019 to 2022
$1.4M
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM125924NIGMS NIH HHS R01 GM135315NIGMS NIH HHS R35 GM150985
6 · The paper itself

Abstract

Nonheme diiron enzymes activate dioxygen (O

Indexed as

Heme Oxygenase (Decyclizing)IronOxygenModels, MolecularOxidation-ReductionSubstrate SpecificityHeme Oxygenase (Decyclizing)IronOxygen

Identifiers

PMID40774922
PMCPMC13420876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.