ArticleVox sanguinis2025
Onsite vasovagal reactions with and without loss of consciousness are distinct outcomes with different risk factors.
Article in Vox sanguinis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects of pre-donation salt-loading on the occurrence of delayed vasovagal reactions.Vox sanguinis · 2026Trial
- Onsite vasovagal reactions with and without loss of consciousness are distinct outcomes with different risk factors.Vox sanguinis · 2025Article
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19 authors.
Funding
Abstract
BACKGROUND AND
objectivesVasovagal reactions (VVRs) are some of the most common adverse reactions (ARs) in blood donors. While researchers have tried to develop precise risk prediction tools, these studies have all combined onsite and offsite reactions as well as reactions with and without the loss of consciousness. This study aimed to investigate potential differences in risk phenotypes in onsite VVRs, here defined as syncope and near-fainting. MATERIALS AND
methodsWe included 40,543 participants from the Danish Blood Donor Study (136 syncope and 1453 near-fainting cases). Data on lifestyle and health were available from questionnaires. Data on donation type, time of day and ARs were available from the blood bank it-system. The risk of VVRs was assessed in a logistic mixed-effects model which included 345,751 donations. For genotyped participants (N = 21,102), polygenic scores were calculated for syncope, anxiety, neuroticism and cardiometabolic disease.
resultsRisk of both types of VVR was found to increase during warmer season and apheresis donation and reduce by donating late in the day. In addition, less donation experience and lower height increased the risk for near-fainting. In contrast, no donor-specific characteristics appeared to mediate the risk of syncope. Genetic predisposition of various traits had no effect on the risk of onsite VVRs.
conclusionThis study indicates that onsite syncope and near-fainting are distinct conditions with different risk profiles. Our findings emphasize the importance of a more detailed analysis of VVRs, suggesting that the common practice of combining VVR subtypes may reduce the accuracy of risk prediction.
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