Evidence map›Paper›PMID 40774813›Full record

ArticleInternational journal for numerical methods in biomedical engineering2025

From Bench Testing to Virtual Implantation: A Comparative Study Between Poly-l-Lactic Acid and Nickel-Titanium Braided Stents.

Agnese Lucchetti, Levi G Juhl, Anna Corti, Alissa Zaccaria, Thomas Gries, Claudio Chiastra, Ted J Vaughan, Dario Carbonaro

Abstract readComparative Study
In one paragraph

Article in International journal for numerical methods in biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Agnese LucchettiInstitut für Textiltechnik of RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-7462-9405
Levi G JuhlInstitut für Textiltechnik of RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0009-0000-6008-0207
Anna CortiDepartment of Electronics, Information and Bioengineering, Milan, Italy.
Alissa ZaccariaConsorzio Intellimech, Bergamo, Italy.ORCID https://orcid.org/0000-0002-3535-4621
Thomas GriesInstitut für Textiltechnik of RWTH Aachen University, Aachen, Germany.
Claudio ChiastraPolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
Ted J VaughanBiomechanics Research Centre (BioMEC), School of Engineering and Institute for Health Discovery and Innovation, College of Science and Engineering, University of Galway, Galway, Ireland.
Dario CarbonaroPolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

Funding

EU Framework Programme for Research and Innovation Marie Sklodowska-Curie ActionsEuropean Union's Horizon 2020 Research and Innovation Programme 813869
6 · The paper itself

Abstract

Bioresorbable braided stents represent a promising solution for the treatment of peripheral artery disease, providing temporary mechanical support before gradually degrading into biocompatible byproducts. Previous studies have highlighted their lower mechanical performance compared to permanent metallic stents. However, their implantation in lower limb arteries remains unexplored, leaving uncertainty on whether their mechanical performance is sufficient for effective treatment. The aim of the present study was to evaluate the performance of a poly-l-lactic acid (PLLA) braided stent for the treatment of lower limb arteries through in silico analysis and compare it with that of a nickel-titanium (NiTi) device. A finite element (FE) model of the PLLA stent was implemented and validated against experimental bench test data. Subsequently, the mechanical characteristics of the PLLA device were compared to those of a NiTi stent, with identical geometrical features, through FE simulations of two bench tests (i.e., parallel plate compression and crimping tests). Finally, a virtual implantation procedure of both devices in a patient-specific lower limb artery was conducted by FE analysis, accounting for three different arterial wall conditions, to compare the stents' treatment performance. The FE analysis of the bench tests confirmed that the PLLA stent generated much lower force magnitudes than the NiTi device. Moreover, the virtual implantation procedure indicated the limited short-term performance of the PLLA stent for the treatment of peripheral artery disease in terms of risk for permanent deformations, low lumen gain, high values of incomplete stent apposition and a nonuniform distribution of contact pressure on the arterial wall.

Indexed as

Lactic AcidNickelPolyestersPolymersStentsTitaniumFinite Element AnalysisHumansMaterials TestingLactic AcidNickelPolyesterspoly(lactide)PolymersTitaniumtitanium nickelidebioresorbable stentfinite element analysisperipheral artery diseasepolymeric stent

Identifiers

PMID40774813
PMCPMC12331417

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.