Evidence map›Paper›PMID 40774806›Full record

ArticleThe European respiratory journal2025

Butyrate-producing gut bacterium

Robert F J Kullberg, Christine C A van Linge, Alex F de Vos, Xanthe Brands, Thi Phuong Nam Bui, Joe M Butler, Daniël R Faber, Aswin Verhoeven, René M van den Wijngaard, Wouter J de Jonge and 4 more

Abstract read
In one paragraph

Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Higher abundance ofmSystems · 2026
    Article
  5. Review
  6. Butyrate Is Associated with the Antidepressant Effects ofInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Article
  9. Frontiers in microbiology · 2026
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Robert F J KullbergCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands r.f.j.kullberg@amsterdamumc.nl.ORCID https://orcid.org/0000-0001-8269-9887
Christine C A van LingeCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Alex F de VosCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Xanthe BrandsCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Thi Phuong Nam BuiDepartment of Experimental Vascular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Joe M ButlerCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-6781-6408
Daniël R FaberDepartment of Internal Medicine, BovenIJ Hospital, Amsterdam, The Netherlands.
Aswin VerhoevenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
René M van den WijngaardTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Wouter J de JongeTytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Max NieuwdorpDepartment of Experimental Vascular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Tom van der PollCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Bastiaan W HaakCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
W Joost WiersingaCenter for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGut microbiota play a protective role against pneumonia in mice, probably by producing the immunomodulatory short-chain fatty acid butyrate. Yet, butyrate has limited potential for clinical use due to its challenging handling in practice. We performed mouse experiments and translational analyses to determine whether butyrate-producing gut commensals,

methodsWe pre-treated C57BL/6J mice with butyrate,

resultsPre-treatment with

conclusionThis is the first study showing that the gut commensal

Indexed as

ButyratesFaecalibacterium prausnitziiGastrointestinal MicrobiomePneumonia, BacterialProbioticsAgedAnimalsDisease Models, AnimalFemaleHumansInterleukin-6Klebsiella InfectionsKlebsiella pneumoniaeMaleMiceMice, Inbred C57BLButyratesInterleukin-6

Identifiers

PMID40774806
PMCPMC12591145

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.