Evidence map›Paper›PMID 40774693›Full record

ArticleJournal for immunotherapy of cancer2025

PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis.

Bing Zhu, Ning Ma, Zhi-Chao Liu, Qian-Wen Zheng, Xin Liang, Yu Chen, Yi-Kang Wang, Hui-Jun Cao, Ji Xia, Sheng Xu and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Bing ZhuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Ning MaDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-1825-8854
Zhi-Chao LiuDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-3542-0905
Qian-Wen ZhengShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Xin LiangShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Yu ChenShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Yi-Kang WangDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hui-Jun CaoShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Ji XiaShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Sheng XuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Xiao-Song QiuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Jing-Yi HuangShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Kai DingShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Yan-Jun XiangDepartment of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.ORCID http://orcid.org/0000-0002-7378-6724
Xi-Ran ZhangShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Lin QiuShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Wei ChenDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xiang WangKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province. Affiliated Hangzhou First People's Hospital, West Lake University School of Medicine, Hangzhou, Zhejiang, China.
Lingyun LongShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Qian-Zhi NiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China tide7@163.com fyao@mail.hzau.edu.cn zhigang.li@shsmu.edu.cn qzni@sinh.ac.cn.
Zhi-Gang LiDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China tide7@163.com fyao@mail.hzau.edu.cn zhigang.li@shsmu.edu.cn qzni@sinh.ac.cn.ORCID http://orcid.org/0000-0001-5086-5334
Fan YaoCollege of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China tide7@163.com fyao@mail.hzau.edu.cn zhigang.li@shsmu.edu.cn qzni@sinh.ac.cn.
Jing-Jing LiShanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China tide7@163.com fyao@mail.hzau.edu.cn zhigang.li@shsmu.edu.cn qzni@sinh.ac.cn.ORCID http://orcid.org/0000-0002-3973-5405

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite a series of attempts during the last decades, the prognosis for esophageal squamous cell carcinoma (ESCC) remains poor. Although clinical immunotherapy trials have shown encouraging results, their benefits are limited. This study aims to identify novel targets for immunotherapy in ESCC. EXPERIMENTAL

designESCC cell lines and mouse models were used to identify the tumor-promoting function of pancreatic progenitor cell differentiation and proliferation factor (PPDPF) and evaluate the effect of blockade of CD24. RNA sequencing was performed to profile transcriptomic changes upon PPDPF deficiency. Fluorescence microscopy-based phagocytosis assay and flow cytometry were employed to analyze macrophage phagocytosis. Immunoblotting, glutathione S-transferase-pulldown assay and co-immunoprecipitation assay were conducted to investigate the mechanism underlying the tumor-promoting role of PPDPF in ESCC. Clinical samples were analyzed to further validate the findings from preclinical models.

resultsThe expression of PPDPF was significantly upregulated in ESCC. Deficiency of PPDPF inhibited the development of ESCC in mice. Mechanistically, PPDPF interfered with the c-Myc-GSK3β interaction and enhanced the protein stability of c-Myc, which increased the expression of CD24 and therefore promoted immune escape from macrophage phagocytosis. Positive correlations between PPDPF, c-Myc, and CD24 were observed in clinical samples. Anti-CD24 monotherapy effectively inhibited the ESCC tumor growth in mice.

conclusionsPPDPF acts as an oncoprotein in ESCC by positively regulating the c-Myc/CD24 axis. These findings provide a potential effective target for immunotherapy in ESCC.

Indexed as

CD24 AntigenEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaProto-Oncogene Proteins c-mycAnimalsCell Line, TumorDisease ProgressionFemaleHumansMaleMiceCD24 AntigenCD24 protein, humanMYC protein, humanProto-Oncogene Proteins c-mycEsophageal CancerImmune Checkpoint InhibitorMacrophage

Identifiers

PMID40774693
PMCPMC12336582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.