Evidence map›Paper›PMID 40774528›Full record

ArticleBiochemistry2025

Metal Ion Requirement for Catalysis by 3'-5' RNA Polymerases.

Brandon W J Iwaniec, Madison M Allegretti, Jane E Jackman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A comparison ofbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Brandon W J IwaniecOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, United States.
Madison M AllegrettiCenter for RNA Biology and Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Jane E JackmanOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0001-9291-8852

Funding

Unlocking evolutionarily latent immune functions for treating diseaseR01CA260414 · NCI · UNIVERSITY OF UTAH · PI BASS, BRENDA L., ELDE, NELS C. · 2020 to 2024
$5.8M
Molecular Mechanism and Biological Function of 3'-5' PolymerasesR01GM087543 · NIGMS · OHIO STATE UNIVERSITY · PI JACKMAN, JANE ELIZABETH · 2010 to 2019
$2.7M
NCI NIH HHS R01 CA260414NIGMS NIH HHS R01 GM087543
6 · The paper itself

Abstract

The two-metal ion mechanism for catalysis of RNA and DNA synthesis by 5'-3' polymerases has been extensively characterized. The 3'-5' polymerase family of enzymes, consisting of tRNA

Indexed as

Cations, DivalentDNA-Directed RNA PolymerasesMetalsNucleotidyltransferasesAdenosine TriphosphateBiocatalysisCatalysisKineticsMagnesiumAdenosine TriphosphateCations, DivalentDNA-Directed RNA PolymerasesMagnesiumMetalsNucleotidyltransferases

Identifiers

PMID40774528
PMCPMC12369627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.