Evidence map›Paper›PMID 40774368›Full record

ArticleActa biomaterialia2025

Macroporous hydrogel-based mRNA cancer vaccine for in situ recruitment and modulation of dendritic cells.

Jiadiao Zhou, Yusheng Liu, Wenhao Xu, Rimsha Bhatta, Joonsu Han, Dhyanesh Baskaran, Savindi Devmal, Cecilia Leal, Hua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiadiao ZhouDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Yusheng LiuDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Wenhao XuDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Rimsha BhattaDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Joonsu HanDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Dhyanesh BaskaranDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Savindi DevmalDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Cecilia LealDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Carle College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Hua WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Cancer Center at Illinois (CCIL), Urbana, IL, 61801, USA; Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Carle College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address: huawang3@illinois.edu.

Funding

Biomaterials for Targeted Modulation of Conventional Type 1 Dendritic CellsR01CA274738 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, HUA · 2022 to 2025
$2.2M
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
Metabolic tagging of tumor exosomes for developing enhanced exosome vaccinesR21CA270872 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WANG, HUA · 2023 to 2024
$364k
NCI NIH HHS R01 CA274738NCI NIH HHS R21 CA270872NIBIB NIH HHS T32 EB019944the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health NIH R21CA270872 (H.W.)the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health NSF DMR 21-43673 CAR (H.W.)the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health R01CA274738 (H.W.)
6 · The paper itself

Abstract

mRNA-based vaccines have demonstrated tremendous success in the era of covid-19, but their full potential for cancer treatment awaits to be realized. To address the low efficiency of conventional mRNA vaccines to encounter and become taken up by dendritic cells in the body, here we report a macroporous hydrogel-based mRNA vaccine that enables in situ recruitment and modulation of dendritic cells. Upon subcutaneous injection of macroporous hydrogels loaded with chemokines and neoantigen-encoding mRNA lipoplexes, high numbers of dendritic cells can be recruited to the gel, take up and process mRNA, and present mRNA-encoded neoantigens in situ, prior to their migration to draining lymph nodes to prime neoantigen-specific CD8

Indexed as

Cancer VaccinesDendritic CellsHydrogelsmRNA VaccinesRNA, MessengerAnimalsAntigens, NeoplasmCell Line, TumorFemaleMiceMice, Inbred BALB CMice, Inbred C57BLNanoparticlesPorosityT-Lymphocytes, CytotoxicAntigens, NeoplasmCancer VaccinesHydrogelsmRNA VaccinesRNA, MessengerCancer vaccineDendritic cellHydrogelImmunotherapymRNA vaccine

Identifiers

PMID40774368
PMCPMC13613483

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.