ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2025
Antibodies to angiotensin II type 1 receptor and endothelin type A receptor are associated with cytokine production enriched for type 2 immune response and antibody production in pediatric kidney transplant recipients.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Biomarkers related to immunosuppression in pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2026Article
- SGLT2i, anti-endothelin A and double endothelin and angiotensin inhibitors: a new future for chronic kidney disease in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- Understanding the role of non-HLA antibodies in kidney transplantation: a literature review.Frontiers in immunology · 2026Review
- Non-human leukocyte antigen antibodies in kidney transplantation: pathogenic mechanisms, detection methods, and clinical implications.Clinical transplantation and research · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Activating antibodies to angiotensin II type 1 receptor (AT1R) and endothelin type A receptor (ETAR) have been associated with rejection, allograft loss, decline in allograft function, and development of human leukocyte antigen donor-specific antibodies in kidney transplantation. Understanding immune dysregulation and inflammatory signatures associated with these antibodies is important for generating targeted investigations of pathogenesis. We investigated a panel of 38 cytokines in a multicenter cohort of 133 pediatric kidney transplant recipients with 1 to 2 years of follow up to further elucidate AT1R and ETAR-Ab-associated inflammatory signatures. Pretransplant and posttransplant blood samples (n = 483) were tested for AT1R-Ab, ETAR-Ab, and 38 cytokines. The relationship between AT1R and/or ETAR-Ab positivity and cytokine elevations were evaluated accounting for demographic and clinical factors. AT1R and/or ETAR-Ab positivity was associated with elevations in 33 of the 38 cytokines, with some elevations resolving or intensifying on posttransplant vs pretransplant samples. Interrogation of these data using z-score comparisons and principal component analyses revealed a strong signal for interleukin (IL)-9, IL-13, IL-5, IL-4, IL-6, lymphotoxin α, and granulocyte-macrophage colony-stimulating factor-cytokines involved with antibody formation and type 2 immune responses. The relationship of this signal to transplant outcomes and impact of adjunctive receptor blockade requires additional investigation.
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