Evidence map›Paper›PMID 40773901›Full record

ArticleJournal of biomechanics2025

A fluid-structure interaction model of the zebrafish aortic valve.

Alexander D Kaiser, Jing Wang, Aaron L Brown, Enbo Zhu, Tzung Hsiai, Alison L Marsden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander D KaiserDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States of America; Stanford Cardiovascular Institute, Stanford, CA, United States of America. Electronic address: alexdkaiser@stanford.edu.
Jing WangDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States of America. Electronic address: jwang20@g.ucla.edu.
Aaron L BrownStanford Cardiovascular Institute, Stanford, CA, United States of America; Department of Mechanical Engineering, Stanford University, Stanford, CA, United States of America. Electronic address: abrown97@stanford.edu.
Enbo ZhuDivision of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States of America. Electronic address: enzhu@mednet.ucla.edu.
Tzung HsiaiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States of America; Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States of America. Electronic address: thsiai@mednet.ucla.edu.
Alison L MarsdenStanford Cardiovascular Institute, Stanford, CA, United States of America; Department of Pediatrics (Cardiology), Stanford University, Stanford, CA, United States of America; Department of Bioengineering, Stanford University, Stanford, CA, United States of America; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, United States of America. Electronic address: amarsden@stanford.edu.

Funding

Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
A multi-physics simulator for pediatric cardiac surgical planningR01HL173845 · NHLBI · STANFORD UNIVERSITY · PI Daniel B Ennis, MICHAEL MA · 2024 to 2026
$2.3M
Integrating Volumetric Light-Field with Computational Fluid Dynamics to Study Myocardial Trabeculation and FunctionR01HL159970 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2021 to 2024
$2.0M
UCLA and Caltech integrated Cardiovascular Medicine for Bioengineers (iCMB)T32HL144449 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, PAJUKANTA, PAIVI · 2020 to 2024
$1.2M
NHLBI NIH HHS R01 HL129727NHLBI NIH HHS R01 HL159970NHLBI NIH HHS R01 HL173845NHLBI NIH HHS T32 HL144449
6 · The paper itself

Abstract

The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction (FSI) simulations are an efficient and highly controllable means to study the function of cardiac valves in development and diseases. Due to their small scales, little is known about the mechanical properties of zebrafish cardiac valves, limiting existing computational studies of zebrafish aortic valves and their interaction with blood. To circumvent these limitations, we took a largely first-principles approach called design-based elasticity that allows us to derive valve geometry, fiber orientation and material properties. In FSI simulations of an adult zebrafish aortic valve, these models produce realistic flow rates when driven by physiological pressures and demonstrate the spatiotemporal dynamics of valvular mechanical properties. These models can be used for future studies of zebrafish cardiac hemodynamics, development, and disease.

Indexed as

Aortic ValveModels, CardiovascularZebrafishAnimalsBiomechanical PhenomenaComputer SimulationElasticityHemodynamicsCardiac modeling and simulationFluid–structure interactionZebrafish aortic valveZebrafish cardiac mechanicsZebrafish outflow tract valve

Identifiers

PMID40773901
PMCPMC12332271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.