Evidence map›Paper›PMID 40773827›Full record

ArticleTranslational oncology2025

Triptonide stabilizes BIM to enhance oxaliplatin-induced ferroptosis and apoptosis in colorectal cancer.

Ji Ma, Liyun Zheng, Shiji Fang, Wenjing Yang, Yiming Ding, Mengyuan Wang, Jiale Chen, Qiaoyou Weng, Zouying Yao, Chuan Jiang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ji MaZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China; Department of Gastrointestinal surgery, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Liyun ZhengZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Shiji FangZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Wenjing YangZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Yiming DingZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Mengyuan WangZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Jiale ChenZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Qiaoyou WengZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Zouying YaoZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Chuan JiangZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of Gastrointestinal surgery, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Minjiang ChenZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China.
Hongtao XuZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of Gastrointestinal surgery, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. Electronic address: xht0071@sina.com.
Jiansong JiZhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, Key Laboratory of Precision Medicine of Lishui City, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China; Department of radiology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. Electronic address: jjstcty@wmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxaliplatin (OXA) is a common chemotherapeutic agent for advanced colorectal cancer. However, its effectiveness is limited by drug resistance, highlighting the need for combination therapies. In this study, Triptonide (TN), a diterpenoid compound is used to enhance the sensitivity of OXA, and the underlying mechanisms are investigated. Our findings indicated the combination of TN and OXA demonstrated strong synergistic anti-tumor effects across a broad concentration range in both HCT116 and LoVo cell lines, particularly at ratios ranging from 1:312 to 1:156. The combination of TN and OXA at low doses effectively inhibits growth and induces cell death in HCT116 and LoVo cells. TN and OXA cotreatment causes severe mitochondrial damage in colorectal cancer cells, leading to intracellular reactive oxygen species (ROS) accumulation, which subsequently triggers apoptosis and ferroptosis. Mechanistically, TN directly binds to BIM, a pro-apoptotic and ferroptotic protein, and stabilizes it. TN treatment led to increased expression of BIM and knockdown of BIM alleviated the growth inhibition of OXA in colorectal cancer cells. Finally, TN and OXA cotreatment significantly reduced the tumor weight and volume of LoVo-bearing nude mice in vivo. Taken together, our findings indicate that TN may serve as a novel therapeutic agent to enhance the efficacy OXA in the treatment of colorectal cancer.

Indexed as

BIMColorectal cancerMitochondrial damageOxaliplatinOxidative stressTriptonide

Identifiers

PMID40773827
PMCPMC12354971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.