ArticleJCO global oncology2025
Treatment Patterns and Outcomes of Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer in Tanzania.
Article in JCO global oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Baseline clinical and laboratory profiles at breast cancer diagnosis in Tanzania: differences by HIV status.Breast (Edinburgh, Scotland) · 2026Article
- Individual-level and community-level factors associated with breast cancer screening among women of reproductive age in Tanzania: a multilevel analysis of the 2022 Tanzania Demographic and Health Survey.BMJ public health · 2026Article
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5 authors.
Funding
Abstract
purposeHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer (HER2+BC) is linked to poorer outcomes. Trastuzumab is the standard treatment, but its high cost limits access in resource-limited settings. This study evaluated the treatment patterns and survival outcomes of patients with HER2 BC in Tanzania. MATERIALS AND
methodsA retrospective hospital-based study was conducted between January 2018 and May 2021 at two prominent public tertiary hospitals in Tanzania. The primary outcome was the 5-year overall survival (OS) rate. Independent variables included demographics, clinical characteristics, and treatment patterns. Survival analysis was conducted using the Kaplan-Meier method. The log-rank test was used in univariate analysis, whereas multivariate Cox regression was used in multivariate analysis.
resultsA total of 169 patients with nonmetastatic HER2+BC were included, with a median age of 50 years. Most patients were estrogen receptor-positive (50.3%) and diagnosed with stage III BC (58.6%). About 70.4% of patients received trastuzumab, whereas neoadjuvant chemotherapy was administered to 24.3%, and 95.9% underwent mastectomy. Trastuzumab was primarily used in the adjuvant setting rather than the neoadjuvant setting and was more accessible to patients with higher socioeconomic status. The 5-year OS was 65%, with a median survival of 72 months. Trastuzumab reduced the mortality risk by 74%. Extended therapy with trastuzumab benefited patients with hormone receptor-negative HER2+BC more than those who were hormone receptor-positive. Advanced-stage disease increased mortality risk, whereas postmenopausal status and nonsmoking were associated with lower mortality. A higher Eastern Cooperative Oncology Group score (>1) was associated with an increased mortality risk.
conclusionTrastuzumab significantly improves OS in resource-limited settings, particularly in patients with hormone receptor-negative HER2+BC. There are disparities in access to trastuzumab in Tanzania.
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