ArticleScience (New York, N.Y.)2025
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice.
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Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed.
- Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.Allergy · 2026Review
- Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target.Allergy · 2026Article
- Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026Review
- Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026Article
- DPEP1 promotes pulmonary fibrosis by regulating arachidonic acid metabolism.Journal of thoracic disease · 2026Article
- Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026Article
- Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy.bioRxiv : the preprint server for biology · 2026Article
- Mouse Models of Food Allergies: Where Do They Take Us?Clinical reviews in allergy & immunology · 2026Review
- Dietary Antigen Interaction with Intestinal Epithelial Cells.Current allergy and asthma reports · 2026Review
- Immune functions of the esophagus.The Journal of allergy and clinical immunology · 2026Review
- Emerging molecular and environmental biomarkers of shrimp allergy in African Americans in the US.Frontiers in allergy · 2026Review
- Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens.Immunological reviews · 2026Review
- Dipeptidase-1 Contributes to Sepsis-Associated Endothelial Dysfunction via the EGR1/NF-κB Signaling Axis.International journal of general medicine · 2026Article
- Gut mucosal immune responses - Implications for celiac disease and food allergy.Seminars in immunology · 2025Review
- Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to ingested antigens.Science (New York, N.Y.) · 2025Article
- A new experimental model of peanut allergy in BALB/c and C57BL/6 mice.Frontiers in allergy · 2025Article
- Emerging diagnostic and therapeutic opportunities in food allergy.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
23 authors.
Laura R HoytDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0350-4154
Elise LiuDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7507-5045
Eli C OlsonThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-2319-7144
Danielle R JacobsenThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-2288-3858
Emily R SiniscalcoDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5065-1854
Rebecca A Krier-BurrisThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-9722-215X
Kara G GreenfieldThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-1315-5146
Caleb D McBrideThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0009-0005-4174-0018
Mia M AlfajaroDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6402-2730
Julien A R AmatDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3154-0803
Zhe ZhaoDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4119-0504
Lan XuDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Vivek PhilipThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0001-5126-707X
Aditi VermaThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-6771-576X
Slim FouratiThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-6609-7587
Donna L SengerLady Davis Institute for Medical Research, Jewish General Hospital, Montreal, PQ, Canada.ORCID 0000-0003-2403-3395
Lingdi ZhangDepartment of Genetics & Genomic Sciences, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Supinda BunyavanichDepartment of Genetics & Genomic Sciences, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6108-439X
Sarah E GlassDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0002-0642-2656
Robert J CoffeyDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0002-2180-3844
Craig B WilenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2495-9403
Adam WilliamsThe Department Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-5151-4103
Stephanie C EisenbarthDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1244-208X
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MYale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0MVanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2019 to 2026
$19.6MThreshold, Severity, and Immunotherapy of Peanut AllergyU19AI136053 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUNYAVANICH, SUPINDA, SICHERER, SCOTT H · 2018 to 2023
$9.1MImmune Mechanisms Regulating AllergyR01AI136942 · NIAID · YALE UNIVERSITY · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2018 to 2026
$5.1MNorthwestern University Allergy Immunology Research Program (NUAIR)T32AI083216 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2010 to 2026
$4.1MDeterminants of oral anaphylaxis to foodR01AI168016 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2023 to 2026
$3.2MThe adaptive immune response to food antigens in the gutR56AI155497 · NIAID · YALE UNIVERSITY · PI EISENBARTH, STEPHANIE CAROLINE · 2021 to 2021
$448kNCI NIH HHS P30 CA016359NCI NIH HHS P30 CA060553NCI NIH HHS P50 CA236733NIAID NIH HHS R01 AI136942NIAID NIH HHS R01 AI168016NIAID NIH HHS R56 AI155497NIAID NIH HHS T32 AI083216NIAID NIH HHS U19 AI136053
Abstract
Food-specific immunoglobulin E (IgE) triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption. We studied strains of mice with different sensitivities to anaphylaxis when orally challenged with allergen to identify possible causes. In resistant C57BL/6 mice, intestinal goblet cells transported less food allergen than did anaphylaxis-susceptible strains, even before allergic sensitization. In a forward genetic screen, resistance was correlated with
Indexed as
AllergensAnaphylaxisCysteineDipeptidasesFood HypersensitivityGPI-Linked ProteinsIntestinal AbsorptionLeukotrienesAnimalsCilastatinGoblet CellsHydroxyureaImmunoglobulin EIntestinal MucosaMiceMice, Inbred C57BLAllergensCilastatinCysteinecysteinyl-leukotrienedipeptidase 1DipeptidasesGPI-Linked ProteinsHydroxyureaImmunoglobulin ELeukotrienesOvalbuminzileuton
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.