Evidence map›Paper›PMID 40773494›Full record

ArticleMolecular plant pathology2025

RepA Protein of Citrus Chlorotic Dwarf-Associated Virus Impairs Perinuclear Chloroplast Clustering Induced by Lemon Chloroplast Malate Dehydrogenase.

Yuan Chen, Jinfa Zhao, Jiajun Wang, Qi Zhang, Mengji Cao, Yan Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular plant pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuan ChenIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University/National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
Jinfa ZhaoIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University/National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
Jiajun WangIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University/National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
Qi ZhangIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University/National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
Mengji CaoIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University/National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University, Chongqing, China.
Yan ZhouIntegrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University/National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University, Chongqing, China.

Funding

China Agriculture Research System-Citrus CARS-26-05BWanzhou District Three Gorges Citrus Technology Research Center's Research and Service Project
6 · The paper itself

Abstract

Replication-related protein A (RepA), encoded by the citrus chlorotic dwarf-associated virus (CCDaV), induces hypersensitive response (HR)-like cell death and defence responses. However, the interactions between the host plant and CCDaV-RepA remain unclear. In this study, Citrus limon chloroplast malate dehydrogenase (ClMDH) was found to interact with CCDaV-RepA in the nucleus. ClMDH induces perinuclear chloroplast clustering (PCC). Moreover, ClMDH suppressed HR-like cell death and the accumulation of reactive oxygen species (ROS) induced by CCDaV-RepA, and promoted the accumulation of CCDaV-RepA. In addition, CCDaV-RepA overexpression altered the subcellular localisation of ClMDH from the chloroplast to the nucleus and inhibited ClMDH-induced PCC. These results reflected the involvement of ClMDH-induced PCC in the host response to CCDaV infection and provide new insights into the interaction between the host and CCDaV.

Indexed as

ChloroplastsCitrusGeminiviridaeMalate DehydrogenaseViral ProteinsCell NucleusGene Expression Regulation, ViralGene LibraryPlant VirusesReactive Oxygen SpeciesRegulatory Elements, TranscriptionalSequence Analysis, ProteinTranscription, GeneticMalate DehydrogenaseReactive Oxygen SpeciesViral Proteinschloroplast malate dehydrogenasecitrus chlorotic dwarf‐associated virusperinuclear chloroplast clusteringreplication‐related protein A

Identifiers

PMID40773494
PMCPMC12330936

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.