ArticlePLoS biology2025
Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.
Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The orbitofrontal-anterior temporal network complements the attention network for where to look in social situations.eNeuro · 2026Article
- Effects of overt and covert attention on decision-making dynamics in prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Compare first, evaluate later: Upending the neuroscience of choice.PLoS biology · 2025Article
- Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.PLoS biology · 2025Article
Corrections and comments
- Commented on by
Authors and funding
2 authors.
Funding
Abstract
Economic decisions often require weighing multiple dimensions, or attributes. The orbitofrontal cortex (OFC) is thought to be important for computing the integrated value of an option from its attributes and comparing values to make a choice. Although OFC neurons are known to encode integrated values, evidence for value comparison has been limited. Here, we used a multi-attribute choice task for monkeys (Macaca mulatta) to investigate how OFC neurons integrate and compare multi-attribute options. By representing attributes with separate cues and using eye tracking to measure attention, we demonstrate that OFC neurons encode the value of attended attributes independent of other attributes in the same option. Encoding was negatively weighted by the value of the matching attribute in the other option, consistent with a comparison between like attributes. These results indicate that OFC computes comparisons between attributes rather than integrated values, and does so dynamically, shifting with the focus of attention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.