Evidence map›Paper›PMID 40773345›Full record

ArticleCell reports2025

A cholinergic spinal pathway for the adaptive control of breathing.

Minshan Lin, Giulia Benedetta Calabrese, Anthony V Incognito, Matthew T Moore, Aambar Agarwal, Richard J A Wilson, Laskaro Zagoraiou, Simon A Sharples, Gareth B Miles, Polyxeni Philippidou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Minshan LinDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
Giulia Benedetta CalabreseSchool of Psychology and Neuroscience, University of St Andrews, St Andrews, UK.
Anthony V IncognitoDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
Matthew T MooreDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
Aambar AgarwalDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
Richard J A WilsonDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
Laskaro ZagoraiouCenter of Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.
Simon A SharplesSchool of Psychology and Neuroscience, University of St Andrews, St Andrews, UK. Electronic address: simon.sharples@cchmc.org.
Gareth B MilesSchool of Psychology and Neuroscience, University of St Andrews, St Andrews, UK. Electronic address: gbm4@st-andrews.ac.uk.
Polyxeni PhilippidouDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, USA. Electronic address: pxp282@case.edu.

Funding

Genetic Control of Respiratory Motor Circuit Development, Connectivity and MaintenanceR01NS114510 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Polyxeni Philippidou · 2020 to 2026
$3.0M
NINDS NIH HHS R01 NS114510
6 · The paper itself

Abstract

The ability to amplify motor neuron (MN) output is essential for generating high-intensity motor actions. This is critical for breathing that must be rapidly adjusted to accommodate changing metabolic demands. While brainstem circuits generate the breathing rhythm, the pathways that directly augment respiratory MN output are not well understood. Here, we map first-order inputs to phrenic motor neurons (PMNs), a key respiratory MN population that initiates diaphragm contraction to drive breathing. We identify a predominant spinal input from a distinct subset of genetically defined V0

Indexed as

Cholinergic NeuronsRespirationSpinal CordAnimalsBrain StemDiaphragmHypercapniaInterneuronsMaleMiceMotor NeuronsPhrenic NerveReceptor, Muscarinic M2Synaptic TransmissionReceptor, Muscarinic M2breathingcholinergic interneuronsCP: Neurosciencemotor circuitsneuromodulationphrenic motor neuronsspinal cord

Identifiers

PMID40773345
PMCPMC12466121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.